Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration

ACS Nano, Journal Year: 2024, Volume and Issue: 18(47), P. 32602 - 32616

Published: Nov. 12, 2024

Insufficient vascularization is a primary cause of bone implantation failure. The management energy metabolism crucial for the achievement vascularized osseointegration. In light semiconductor property and electric heterojunctions, three-dimensional heterojunction network (3D-NTBH) implant has been devised with objective regulating cellular metabolism, thereby driving angiogenesis regeneration. interfaces facilitate electron transfer establish internal fields at nanoscale interfaces. 3D-NTBH was found to noticeably accelerate glycolysis in endothelial cells, rapidly providing support metabolic activities ultimately within tissue. Molecular dynamic simulations have demonstrated that facilitates exposure fibronectin's Arg-Gly-Asp peptide binding site, cells. Further evidence suggests promotes early vascular reconstruction regeneration vivo. findings this research offer promising perspective design vascularizing implants.

Language: Английский

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Hydrogel promotes bone regeneration through various mechanisms: a review

Biomedical Engineering / Biomedizinische Technik, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Large defects in bone tissue due to trauma, tumors, or developmental abnormalities usually require surgical treatment for repair. Numerous studies have shown that current repair and regeneration treatments certain complications limitations. With the in-depth understanding of mechanisms biological materials, a variety materials with desirable physicochemical properties functions emerged field recent years. Among them, hydrogels been widely used research their biocompatibility, unique swelling properties, ease fabrication. In this paper, development classification were introduced, mechanism promoting was described detail, including promotion marrow mesenchymal stem cell differentiation, angiogenesis, enhancement activity morphogenetic proteins, regulation microenvironment tissues. addition, future direction hydrogel engineering discussed.

Language: Английский

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Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 33 - 54

Published: Nov. 30, 2024

Sufficient vascular system and adequate blood perfusion is crucial for ensuring nutrient oxygen supply within biomaterials. Actively exploring the optimal physical properties of biomaterials in various application scenarios has provided clues enhancing vascularization materials, leading to improved outcomes tissue engineering clinical translation. Here we focus on reviewing biomaterials, including pore structure, surface topography, stiffness, their effects promoting vascularization. This angiogenic capability potential provide better standardized research models personalized treatment strategies bone regeneration, wound healing, islet transplantation cardiac repair.

Language: Английский

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Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 584 - 598

Published: Dec. 25, 2024

Language: Английский

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