Near-Infrared Responsive Properties of Bone Repair Scaffolds Facilitated by Specific Osteoinductive Photothermal Converters for Highly Efficient Bone Repair DOI
Peng Xue,

Hongzhong Xi,

Xiaoxue Tan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 37581 - 37595

Published: July 10, 2024

The effective repair of bone defects has long been a major challenge in clinical practice. Currently, research efforts mostly focus on achieving sufficiently good repair, with little attention paid to both and fast repair. However, highly efficient (H-efficient) which is fast, can shorten the treatment cycle facilitate rapid patient recovery. Therefore, development H-efficient material significant importance. This study incorporated previously developed osteoinductive photothermal agent (PTA) BPICT into printing paste prepare near-infrared (NIR)-responsive scaffold. Subsequently, effects therapy (PTT) drug release were assessed vitro. To further validate properties scaffold, scaffold was implanted its ability promote vivo evaluated through radiology histopathological analysis. results indicated that compared scaffolds containing only Icaritin (ICT), achieve PTT NIR irradiation, while also enabling controlled ICT from enhance Within same observation period, achieves more than significantly shortening ensuring effectiveness NIR-responsive based PTT-mediated growth factors represents feasible solution for promoting area defects.

Language: Английский

Advances in Pharmacological Research on Icaritin: A Comprehensive Review DOI
Ran Guo, Zhiping Yan,

Rui Wang

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 29, 2025

Epimedium has been widely used in traditional Chinese medicine for several thousands of years. This plant is known tonifying kidney Yang, strengthening muscles and bones, dispelling wind dampness. It worth noting that icaritin, a prenylated flavonoid isolated from Epimedium, received increasing attention recent years due to its wide range pharmacological activities. Icaritin exhibits significant therapeutic potential against various diseases, such as osteoporosis, tumors (hepatocellular carcinoma, stomach cancer, breast glioblastoma), cerebral ischemia skin injury, thrombocytopenia, systemic lupus erythematosus. We review the activities icaritin molecular mechanisms treatment related diseases. The data suggest can have effects mediating Wnt/[Formula: see text]-catenin, IL-6/JAK2/STAT3, AMPK/mTOR, PTEN/AKT, MAPK, NF-[Formula: text]B, other signaling pathways. paper also discusses progress clinical trials icaritin. was approved by State Food Drug Administration January 2022 advanced HCC, drug prospects. Although it some disadvantages, including poor solubility, low bioavailability, still prospective candidate development naturally derived drugs, especially inflammatory aims update deepen understanding provide theoretical basis further study.

Language: Английский

Citations

0
Functionalized BP@(Zn+Ag)/EPLA Nanofibrous Scaffolds Fabricated by Cryogenic 3D Printing for Bone Tissue Engineering DOI
Shunyu Chen,

Zhoucheng Qiu,

Lihua Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract This study fabricates a functionalized scaffold by cryogenic three‐dimensional (3D) printing using an aminated poly‐L‐lactic acid (EPLA) solution containing nanosilver/zinc‐coated black phosphorus (BP@(Zn+Ag)) nanocomposites. The nanocomposites are prepared green method of in situ photodeposition silver and zinc nanoparticles (AgNPs ZnNPs) on BP nanosheets (BPNs) under visible light irradiation without any chemical reductant. Scanning electron microscope (SEM) X‐ray energy dispersive spectrometer (EDS) confirm the uniform distribution BP@(Zn+Ag) EPLA nanofibrous matrix. vitro tests show that fabricated BP@(Zn+Ag)/EPLA exhibits excellent antibacterial activity (over 96%) against E. coli S. aureus, as well enhanced cell viability osteogenic to facilitate growth differentiation osteoblasts. vivo rat calvarial defect model also demonstrates promotes new bone tissue formation around implant site. Therefore, multifunctional 3D printed has great potential for engineering (BTE) applications.

Language: Английский

Citations

3
Dynamic Cross-Linking, Self-Healing, Antibacterial Hydrogel for Regenerating Irregular Cranial Bone Defects DOI
Zuoxiang Dong, Jian Xu, Peng Lun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39035 - 39050

Published: July 19, 2024

Given the widespread clinical demand, addressing irregular cranial bone defects poses a significant challenge following surgical procedures and traumatic events. In situ-formed injectable hydrogels are attractive for due to their ease of administration ability incorporate ceramics, ions, proteins into hydrogel. this study, multifunctional hydrogel composed oxidized sodium alginate (OSA)-grafted dopamine (DO), carboxymethyl chitosan (CMCS), calcium ions (Ca2+), nanohydroxyapatite (nHA), magnesium oxide (MgO) (DOCMCHM) was prepared address via dynamic Schiff base chelation reactions. DOCMCHM exhibits strong adhesion wet tissues, self-healing properties, antibacterial characteristics. Biological evaluations indicate that has good biocompatibility, in vivo degradability, promote cell proliferation. Importantly, hydrogel, containing MgO, promotes expression osteogenic protein markers COL-1, OCN, RUNX2, stimulates formation new blood vessels by upregulating CD31. This study could provide meaningful insights ion therapy repair defects.

Language: Английский

Citations

3
Immunoregulation in Skull Defect Repair with a Smart Hydrogel Loaded with Mesoporous Bioactive Glasses DOI Creative Commons
Shiguo Yuan, Boyuan Zheng, Kai Zheng

et al.

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Skull defect repair is a complex and critical medical challenge, there an urgent need to develop multifunctional tissue engineering scaffolds for skull regeneration. The success of bone depends on the construction that can regulate immune microenvironment regeneration mimic liquid crystal viscoelastic properties natural extracellular matrix. Hence, smart hydrogel (PEGDA5/AM15/CLC-BMP-4@MBG) with good biocompatibility ability modulate wound has been developed defects. consists chitin (PEGDA5/AM15/CLC) mesoporous bioactive glasses (MBGs) loaded morphogenetic protein-4 (BMP-4). not only offers necessary biological support mechanical but also maintains stability state, facilitating adhesion surrounding tissue. In addition, BMP-4@MBG intelligently regulates release rate BMP-4 in response changes microenvironment, thus effectively promoting transformation macrophages from M1 M2 macrophages. At same time, Ca 2+ Si 4+ released by MBG degradation synergically promote process. PEGDA5/AM15/CLC-BMP-4@MBG shows excellent immunomodulatory osteogenic promising scaffold material engineering.

Language: Английский

Citations

2
Near-Infrared Responsive Properties of Bone Repair Scaffolds Facilitated by Specific Osteoinductive Photothermal Converters for Highly Efficient Bone Repair DOI
Peng Xue,

Hongzhong Xi,

Xiaoxue Tan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 37581 - 37595

Published: July 10, 2024

The effective repair of bone defects has long been a major challenge in clinical practice. Currently, research efforts mostly focus on achieving sufficiently good repair, with little attention paid to both and fast repair. However, highly efficient (H-efficient) which is fast, can shorten the treatment cycle facilitate rapid patient recovery. Therefore, development H-efficient material significant importance. This study incorporated previously developed osteoinductive photothermal agent (PTA) BPICT into printing paste prepare near-infrared (NIR)-responsive scaffold. Subsequently, effects therapy (PTT) drug release were assessed vitro. To further validate properties scaffold, scaffold was implanted its ability promote vivo evaluated through radiology histopathological analysis. results indicated that compared scaffolds containing only Icaritin (ICT), achieve PTT NIR irradiation, while also enabling controlled ICT from enhance Within same observation period, achieves more than significantly shortening ensuring effectiveness NIR-responsive based PTT-mediated growth factors represents feasible solution for promoting area defects.

Language: Английский

Citations

0