Developmental Dynamics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
The
rising
incidence
of
Alzheimer's
disease
(AD)
and
the
associated
economic
impacts
has
prompted
a
global
focus
in
field.
In
recent
years,
there
been
growing
understanding
pathogenic
mechanisms
AD,
including
aggregation
β-amyloid,
hyperphosphorylated
tau,
neuroinflammation.
These
processes
collectively
lead
to
neurodegeneration
cognitive
decline,
which
ultimately
results
loss
autonomy
patients.
Currently,
are
three
main
types
AD
treatments:
clinical
tools,
pharmacological
treatment,
material
interventions.
This
review
provides
comprehensive
analysis
underlying
etiology
pathogenesis
as
well
an
overview
current
prevalence
treatments.
We
believe
this
article
can
help
deepen
our
mechanism,
facilitate
translation
scientific
research
or
therapies,
address
problem
AD.
The Innovation Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100121 - 100121
Published: Jan. 1, 2025
<p>In
recent
decades,
the
incidence
of
neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD)
has
risen
continuously,
significantly
impairing
patients’
quality
life
while
imposing
growing
economic
social
burdens.
Traditional
treatments
exhibit
limited
effectiveness
in
halting
progression.
Non-invasive
neuromodulation
techniques,
utilizing
electromagnetic
fields,
light,
or
ultrasound,
have
emerged
promising
strategies
to
modulate
neural
activity
alleviate
symptoms.
However,
achieving
spatially
precise
targeted
remains
challenging.
The
integration
stimuli-responsive
nanoplatforms
addresses
this
limitation.
These
nanoplatforms,
engineered
respond
specific
stimuli,
can
deliver
therapeutic
agents
desired
brain
regions.
By
enabling
controlled
localized
drug
release,
they
facilitate
neuromodulation.
Despite
their
potential,
several
hurdles
must
be
overcome,
including
optimization
nanoplatform
design,
elucidating
complex
nanoplatform-brain
interactions,
ensuring
long-term
safety
efficacy.
Nonetheless,
combining
non-invasive
with
holds
revolutionary
potential
for
therapy,
offering
targeted,
personalized
that
may
halt
slow
This
comprehensive
review
explores
applications
assisted
by
exogenous
AD
PD
therapy.</p>
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Abstract
The
prevalence
of
neurological
dieases,
including
neurodegenerative,
neurotraumatic
disorders,
and
neuroinflammatory
conditions,
has
been
rising
due
to
global
population
aging
demographics.
A
key
factor
in
the
pathogenesis
these
disorders
is
hyperaccumulation
reactive
oxygen
nitrogen
species
(RONS).
Nanozymes
have
emerged
as
promising
candidates
for
neurotherapeutic
applications
owing
their
exceptional
catalytic
activity
stability.
Of
particular
note
ability
cross
blood‐brain
barrier
counteract
production
via
enzyme‐mimicking
characteristics.
In
this
review,
latest
advancements
theoretical
knowledge
research
domain
are
summarized.
Using
inherent
functionalities
Web
Science
bibliometric
methodologies,
annual
publication
trends
identified
extensively
explored
most
researched
topics
field.
antioxidant
reduction
chemistry
nanozymes
discussed,
highlighting
mimic
natural
oxidoreductase
inhibit
RONS
at
source.
Moreover,
review
delves
into
current
limitations
future
prospects
mechanisms
addressing
disorders.
significant
benefits
recent
developments
use
RONS‐regulating
treatment
diseases
emphasized,
offering
insights
therapeutic
broader
implications
neurology.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
Traditional
Chinese
medicine
(TCM)
has
been
employed
for
centuries
in
treating
and
managing
Alzheimer's
disease
(AD).
However,
their
effective
delivery
to
target
sites
can
be
a
major
challenge.
This
is
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Furthermore,
the
blood-brain
barrier
(BBB)
obstacle
TCM
delivery,
significantly
reducing
efficacy.
Advancements
nanotechnology
its
applications
(nano-TCM)
deliver
active
ingredients
or
components
of
across
BBB
targeted
brain
area.
review
summarizes
recent
advances
nanocarrier-based
systems
different
types
constituents
AD,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones.
Besides,
main
challenges
opportunities
future
development
these
advanced
nanocarriers
are
emphasized.
In
conclusion,
this
provides
valuable
insights
guidance
utilizing
shape
drug
delivery.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 21
Published: Dec. 8, 2024
Photothermal
therapy
(PTT)
has
recently
garnered
significant
attention
as
a
prominent
noninvasive
treatment
modality
for
broad
spectrum
of
diseases.
Despite
the
increasing
volume
scholarly
output
over
last
20
years,
holistic
synthesis
that
delineates
worldwide
research
trajectories
remains
elusive.
We
undertook
bibliometric
analysis
literature
from
2004
to
2023,
aiming
delineate
prevailing
focal
points
and
illuminate
prospective
avenues.
Research
articles
on
PTT
were
retrieved
Web
Science
Core
Collection.
Using
tools
such
CiteSpace,
VOSviewer,
Bibliometrix,
we
comprehensively
analyzed
visualized
11,184
published
academic
papers.
China
highest
number
publications.
Journals
related
are
primarily
comprised
interdisciplinary
comprehensive
journals.
associated
with
focused
its
antitumor
properties.
Current
areas
in
this
domain
include
synergistic
combination
photodynamic
therapy,
immunological
mechanisms
enhance
therapeutic
efficacy,
integrated
use
nanoenzyme
catalysis,
role
antimicrobial
applications.
This
provides
an
initial
examination
medical
applications
PTT,
offering
insights
into
global
landscape,
key
interest,
emerging
trends,
thereby
serving
valuable
reference
future
studies
field.
