Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 10, 2024
As
the
population
ages,
occurrence
of
osteoporosis
is
becoming
more
common.
Diabetes
mellitus
one
factors
in
development
osteoporosis.
Compared
with
general
population,
incidence
significantly
higher
diabetic
patients.
Diabetic
(DOP)
a
metabolic
bone
disease
characterized
by
abnormal
tissue
structure
due
to
hyperglycemia
and
insulin
resistance,
reduced
strength
increased
risk
fractures.
This
complex
mechanism
that
occurs
at
cellular
level
such
as
blood
vessels,
inflammation,
resistance.
Although
application
some
drugs
clinical
practice
can
reduce
DOP,
fractures
caused
DOP
still
very
high.
Extracellular
vesicles
(EVs)
are
new
communication
mode
between
cells,
which
transfer
miRNAs
proteins
from
mother
cells
target
through
membrane
fusion,
thereby
regulating
function
cells.
In
recent
years,
role
EVs
pathogenesis
has
been
widely
demonstrated.
this
article,
we
first
describe
changes
microenvironment
Second,
DOP.
Finally,
summarize
research
progress
challenges
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Osteoporosis
(OP)
is
a
systemic
disease
characterized
by
decreased
bone
density
and
quality,
leading
to
fragile
bones
osteoporotic
fractures
(OPF).
Conventional
treatments
for
OPF
often
exhibit
limited
therapeutic
efficacy
significant
side
effects.
Synthetic
biology-based
bacterial
extracellular
vesicles
(BEVs)
offer
safe
effective
alternative
treatment.
Here,
we
constructed
bioengineered
BEVs
loaded
with
pBMP-2-VEGF
(BEVs-BP)
encapsulated
them
together
IL-4
in
GelMA
hydrogels
form
IL-4/BEVs-BP@GelMA.
Initially,
alleviated
chronic
inflammation
modulating
immune
cells,
while
BEVs-BP
subsequently
enhanced
osteogenesis
vascularization
upregulating
BMP-2
VEGF
expression.
In
vitro,
IL-4/BEVs-BP@GelMA
polarized
M1
macrophages
toward
the
M2
phenotype,
osteogenesis,
increased
angiogenesis.
Moreover,
effectively
promoted
maturation
mineralization
of
organoids
vivo.
Finally,
successfully
accelerated
fracture
repair
mice.
summary,
developed
an
easy-to-build
powerful
biomaterial,
IL-4/BEVs-BP@GelMA,
which
offers
strategy
management.
Journal of Holistic Integrative Pharmacy,
Journal Year:
2024,
Volume and Issue:
5(2), P. 141 - 147
Published: June 1, 2024
Rheumatic
immune
disorders
are
a
group
of
conditions
that
affect
the
system,
leading
to
various
clinical
symptoms.
These
diseases
can
cause
pain,
reduce
quality
life,
and
increase
risk
death
in
severe
cases.
Diagnosis
treatment
very
complex
due
different
types
disease
individual
differences
unknown
pathogenesis
disease.
Further
research
is
necessary
provide
new
clues
for
treatment.
Organoid
technology
makes
up
shortcomings
animal
model
species
better
simulate
onset
mechanisms
than
models.
It
be
used
as
screening
platform
therapeutic
targets,
well
personalized
settings
based
on
patient-derived
organoids,
promising
an
effective
tool
study
rheumatic
diseases.
Therefore,
article
summarizes
studies
related
organoids
their
application
also
provides
outlook
potential
this
field
discusses
challenges
need
addressed,
putting
ideas
future
these
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10497 - 10512
Published: Oct. 1, 2024
Cinobufagin,
the
primary
active
compound
in
toad
venom,
is
commonly
used
for
anti-tumor,
anti-inflammatory,
and
analgesic
purposes.
However,
its
specific
bone-protective
effects
remain
uncertain.
This
research
aims
to
ascertain
properties
of
cinobufagin
investigate
underlying
mechanisms.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 10, 2024
As
the
population
ages,
occurrence
of
osteoporosis
is
becoming
more
common.
Diabetes
mellitus
one
factors
in
development
osteoporosis.
Compared
with
general
population,
incidence
significantly
higher
diabetic
patients.
Diabetic
(DOP)
a
metabolic
bone
disease
characterized
by
abnormal
tissue
structure
due
to
hyperglycemia
and
insulin
resistance,
reduced
strength
increased
risk
fractures.
This
complex
mechanism
that
occurs
at
cellular
level
such
as
blood
vessels,
inflammation,
resistance.
Although
application
some
drugs
clinical
practice
can
reduce
DOP,
fractures
caused
DOP
still
very
high.
Extracellular
vesicles
(EVs)
are
new
communication
mode
between
cells,
which
transfer
miRNAs
proteins
from
mother
cells
target
through
membrane
fusion,
thereby
regulating
function
cells.
In
recent
years,
role
EVs
pathogenesis
has
been
widely
demonstrated.
this
article,
we
first
describe
changes
microenvironment
Second,
DOP.
Finally,
summarize
research
progress
challenges
