Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine DOI Creative Commons
Jingkai Zhang, Chang Liu, Jun Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, organs. Known its highly oriented hierarchical structure, collagen in natural bones produces local electrical signals to stimulate osteoblasts promote bone formation, inspiring application of orthopedic medicine. Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, other signaling pathways. This review thus focuses on discussing pioneering applications diagnosis treatment diseases, aiming offer valuable insights advancing next‐generation medical technologies. Beginning an introduction principles various materials, this paper delves into mechanisms which accelerated osteogenesis. A comprehensive overview devices, systems enhancing tissue repair, alleviating inflammation at infection sites, monitoring health is then provided, respectively. Finally, major challenges faced conditions are thoroughly discussed, along a critical outlook future development trends.

Language: Английский

Synergistic combinational photothermal therapy-based approaches for cancer treatment DOI Creative Commons
Gaurisha Alias Resha Ramnath Naik, Ashutosh Gupta, Deepanjan Datta

et al.

FlatChem, Journal Year: 2025, Volume and Issue: unknown, P. 100834 - 100834

Published: Feb. 1, 2025

Language: Английский

Citations

1
Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review DOI
Junfei Li,

Yajie Xie,

Guodong Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 38852 - 38879

Published: July 23, 2024

Biophysical and clinical medical studies have confirmed that biological tissue lesions trauma are related to the damage of an intrinsic electret (i.e., endogenous electric field), such as wound healing, embryonic development, occurrence various diseases, immune regulation, regeneration, cancer metastasis. As exogenous electrical signals, conductivity, piezoelectricity, ferroelectricity, pyroelectricity, bioelectroactives can regulate field, thus controlling function cells promoting repair regeneration tissues. Materials, once polarized, harness their inherent polarized static fields generate field through direct stimulation or indirect interactions facilitated by physical friction, ultrasound, mechanical stimulation. The interaction with microenvironment allows for regulation compensation signals in damaged microenvironments, leading repair. technique shows great promise applications regeneration. In this paper, generation change electroactive substances expounded, latest research progress its effects include bone repair, nerve drug penetration promotion, etc. Finally, opportunities challenges materials were summarized. Exploring development new mechanism regulating changes may provide insights innovative methods disease treatment applications.

Language: Английский

Citations

4
Relationship of Chronic Stress and Hypertension with Bone Resorption DOI Creative Commons
M. Paulini,

Mariangeles Aimone,

Sara Feldman

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 21 - 21

Published: Jan. 4, 2025

Background/Objectives: Chronic exposure to stress has been considered a risk factor for hypertension, which is also associated with increased bone resorption. This review aimed investigate the effect of acute and chronic stress, on skeletal system. Methods: A comprehensive search was conducted across multiple databases, focusing peer-reviewed articles published in English. We include experimental, clinical, studies focused relationship between Searches were MEDLINE via PubMed, Embase Scopus, last completed 10 September 2024. Results: The main topics situations that favor loss, such as psychological can lead osteoporotic fractures through immunological endocrine mechanisms. loss density, osteoporosis, occurs due reduction number osteoblasts balance physiological formation/resorption. Conclusions: significantly affects cardiovascular health narrative study highlights vulnerability system, along prolonged emphasizing need multidisciplinary strategies preventing stress-related conditions. Effective management help reduce risks disease resorption, their role care.

Language: Английский

Citations

0
Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release DOI
Yu Zhuang, Dingwei Wu,

Lvyang Zhou

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by distinctive characteristics of healing staged defects structure–function relationship natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) promote regeneration defects. Here, inner layer was using coaxial electrospinning fibers, with shell incorporating zinc oxide nanoparticles (ZnO NPs) core containing silicon dioxide (SiO2 mimicking cambium periosteum; outer consisted randomly aligned fibers loaded deferoxamine (DFO), simulating fibrous finally, epigallocatechin-3-gallate (EGCG) coated onto membrane obtain Bilayer@E. presence EGCG on Bilayer@E surface efficiently triggers phenotypic transition macrophages, shifting them from M1 proinflammatory state M2 anti-inflammatory state. Moreover, sequential release ZnO NPs, DFO, SiO2 NPs exhibits antimicrobial while coordinating angiogenesis promoting mineralization cells. Importantly, shows strong vivo tissue periosteal properties rats. integration drug immunomodulation, tailored meet specific requirements during regeneration, offers new insights for advancing application biomaterials this field.

Language: Английский

Citations

0
Ultrasound Activated Piezoelectric Catalysis and Neurogenic Activity for Effective Therapy of MRSA Infected Bone Defects by Phase/Defect‐Engineered Barium Strontium Titanate DOI Open Access
Yan Xu, Chao Xu, Mao Xie

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Infected bone defects are a growing global health issue, with risks including destruction, disability, and even death. The main clinical challenge is the difficulty in simultaneously achieving effective antibacterial action promoting regeneration. Calcination at 800°C induces phase transition from cubic (C‐BSTO) to polarized tetragonal (T‐BSTO), imparting piezoelectric properties. Subsequent treatment sodium borohydride generates oxygen vacancies, enhancing polarization performance. synthesized T‐BSTO‐V o achieves 99.83% efficiency against methicillin‐resistant Staphylococcus aureus (MRSA) under 1.5 W cm² ultrasound (US) irradiation for 20 min. Mild US activates signal, Schwann cell (SC) neurogenic differentiation via PI3K‐AKT signaling intracellular Ca²⁺ elevation. Further studies showed that synergy of neurotransmitter SCs electric signal increased osteogenic human marrow mesenchymal stem cells (BMSCs). Consequently, US‐irradiated effectively promotes innervated regeneration MRSA‐infected defect model through rapidly killing bacteria, modulating immune microenvironment. This study offers new approach developing bioactive sonosensitizers phase/defect engineering, treats enhanced piezocatalytic effect

Language: Английский

Citations

0
Deciphering the skeletal interoceptive circuitry to control bone homeostasis DOI Creative Commons

Yefeng Wu,

Jiusi Guo, Zhen Chen

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Bone tissue is richly innervated, and the influence of nervous system on physiological pathological status bone has emerged as a significant research focus. The recent discovery skeletal interoceptive circuits further emphasizes crucial role central in control homeostasis. Skeletal interoception represents one most intricate mechanisms human body for maintaining homeostasis, it involves orchestrated efforts skeletal, nervous, immune, endocrine systems. In this review, we comprehensively introduce three primary components circuitry, including ascending pathways that perceive convey signals to system, neural process interpret these signals, descending mediate regulatory effects tissue. We also discuss how innovative therapeutic strategies can be developed modulate homeostasis by leveraging updated findings circuitry. anticipate application knowledge will lead paradigm shift field orthopaedics biomaterials.

Language: Английский

Citations

0
End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration DOI

Jianyang Shan,

Liang Cheng, Xiang Li

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 486 - 501

Published: March 20, 2025

Language: Английский

Citations

0
Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications DOI Open Access
Kai Mao, Muxin Yue, Huiping Ma

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Language: Английский

Citations

0
Self-degradable nanoparticles hybrid hydrogel with cascade thermal control and spontaneous ion release for complex bone defect regeneration DOI
Shuhan Yang, Zheng Zheng, Min Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162653 - 162653

Published: April 1, 2025

Language: Английский

Citations

0
Bioinspired poly(lactic acid)/silk fibroin-based dressings with wireless electrical stimulation and instant self-adhesion for promoting wound healing DOI Creative Commons
Xiaowei Huang,

Yankun Zheng,

Jinfa Ming

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 223, P. 120179 - 120179

Published: Dec. 3, 2024

Language: Английский

Citations

3