Nanozyme-based sensors for cancer diagnosis

Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: 19, P. 100512 - 100512

Published: July 2, 2024

Many biosensor technologies that can precisely and sensitively identify biomarkers reflecting disease status are being developed to help with early cancer detection anticancer treatment monitoring. The creation of sensors based on nanozymes is one the novel approaches in intricate diagnosis cancers. Because natural enzyme be unstable expensive, use biosensors offers a great substitute for this type study. Nanozymes have stable shelf life, operational reliability, cheap cost, outstanding catalytic activity. technological generating their briefly described paper. A summary many kinds diverse nanomaterials identification provided, along discussion latest developments challenges field nanozyme diagnosis.

Language: Английский

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Carbon-based nanozymes for cancer therapy and diagnosis: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139704 - 139704

Published: Jan. 1, 2025

Language: Английский

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Emerging Roles of Nanozyme in Tumor Metabolism Regulation: Mechanisms, Applications, and Future Directions

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Nanozymes, nanomaterials with intrinsic enzyme activity, have garnered significant attention in recent years due to their catalytic abilities comparable natural enzymes, cost-effectiveness, high activities, and stability against environmental fluctuations. As functional analogs of nanozymes participate various critical metabolic processes, including glucose metabolism, lactate the maintenance redox homeostasis, all which are essential for normal cellular functions. However, disruptions these pathways frequently promote tumorigenesis progression, making them potential therapeutic targets. While several therapies targeting tumor metabolism currently clinical or preclinical stages, efficacy requires further enhancement. Consequently, that target regarded as a promising strategy. Despite extensive studies investigating application relevant reviews relatively scarce. This article first introduces physicochemical properties biological behaviors nanozymes. Subsequently, we analyze role explore applications therapy. In conclusion, this review aims foster innovative research related fields advance development nanozyme-based strategies cancer diagnostics therapeutics.

Language: Английский

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Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Language: Английский

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Nanohybrid Uric Oxidase with Magnetically Switchable Catalytic Potential for Precise Gout Therapy

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123277 - 123277

Published: March 1, 2025

Language: Английский

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Longitudinal Multi-Omics Analysis of the Gut-Liver Axis: Unraveling the Molecular Mechanisms of Metabolic Homeostasis Regulation by Pd@Pt Nanozymes

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101685 - 101685

Published: March 19, 2025

Language: Английский

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IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Nanozymes with peroxidase (POD)-like activity hold significant potential for addressing antibiotic-resistant bacterial infections. However, their catalytic efficiency and therapeutic efficacy need further improvement to broaden clinical applications. A key challenge is achieving efficient energy transfer from photosensitizing molecules nanozymes, which critical enhancing performance. In this study, a universal strategy developed bridge nanozymes molecules, designing photoactivated called IR820/PDA@mCeO2 (IR/P@Ce). By integrating IR820, photosensitizer, mesoporous ceria (mCeO2), it facilitates electron through polydopamine (PDA) resulting in enhanced POD-like performance reactive oxygen species production. Additionally, PDA stabilized the nanozyme, improved photothermal therapy, photodynamic therapy under near-infrared light exposure, amplifying destruction. This multifunctional nanozyme demonstrated strong antibacterial against both Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. Moreover, its synergistic approach not only facilitated eradication but also accelerated wound healing vivo, making promising alternative managing infections promoting tissue regeneration.

Language: Английский

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Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142798 - 142798

Published: April 1, 2025

Language: Английский

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Theranostics of osteoarthritis: Applications and prospects of precision targeting nanotechnology

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125548 - 125548

Published: April 1, 2025

Language: Английский

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Nanozymes: Innovative Therapeutics in the Battle Against Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3522 - 3522

Published: April 9, 2025

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), amyotrophic lateral (ALS) and Huntington’s (HD), represent a significant challenge to global health due their progressive nature the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, neuroinflammation, which collectively contribute neuronal damage death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores multifaceted roles nanozymes combating stress inflammation neurodegenerative conditions. By harnessing potent antioxidant properties, can effectively scavenge reactive oxygen species (ROS) restore redox balance, thereby protecting function. Their ability modify surface properties enhances targeted delivery biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on design, functionality, potential nanozymes, emphasizing dual role addressing pathological features such as aggregation. synthesis current research underscores innovative proactive strategy halt progression improve patient outcomes disorders.

Language: Английский

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