Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101553 - 101553
Published: Feb. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Establishing
an
optimized
regenerative
microenvironment
for
pulp-dentin
complex
engineering
has
become
increasingly
critical.
Recently,
exosomes
have
emerged
as
favorable
biomimetic
nanotherapeutic
tools
to
simulate
the
developmental
and
facilitate
tissue
regeneration.
This
study
aimed
elucidate
multifaceted
roles
of
from
human
dental
pulp
stem
cells
(DPSCs)
that
initiated
odontogenic
differentiation
while
sustaining
mesenchymal
cell
(MSC)
characteristics
in
odontogenesis,
angiogenesis,
neurogenesis
during
Differential
centrifugation
was
performed
isolate
normal
DPSCs
(DPSC-Exos)
initially
triggered
(DPSC-Od-Exos).
The
impact
these
on
biological
behavior
umbilical
vein
endothelial
(HUVECs)
examined
vitro
through
CCK-8
assay
Transwell
migration
assay,
well
assays
dedicated
assessing
odontogenic,
angiogenic,
neurogenic
capabilities.
In
vivo,
Matrigel
plugs
tooth
root
fragments
incorporating
either
DPSC-Exos
or
DPSC-Od-Exos
were
subcutaneously
transplanted
into
mouse
models.
Subsequent
histological,
immunohistochemical,
immunofluorescent
analyses
conducted
determine
outcomes.
revealed
no
remarkable
difference
their
characteristics.
indicated
significantly
facilitated
proliferation,
migration,
multilineage
compared
with
DPSC-Exos.
Furthermore,
elicited
a
more
pronounced
effect
tubular
structure
formation
HUVECs.
Consistently,
plug
confirmed
exhibited
superior
performance
promoting
stimulating
angiogenesis
Notably,
contributed
complete
regeneration
fragments,
characterized
by
enriched
neurovascular
structures
continuous
layer
odontoblast-like
cells,
which
extended
cytoplasmic
projections
newly
formed
dentinal
tubules.
By
simulating
microenvironment,
multifunctional
demonstrated
promising
potential
reconstructing
dentin-like
tissue,
vascular
networks,
neural
architectures,
thereby
enhancing
our
understanding
therapeutic
implications
endodontic
treatment.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Abstract
Infections
caused
by
persistent,
drug‐resistant
bacteria
pose
significant
challenges
in
inflammation
treatment,
often
leading
to
severe
morbidity
and
mortality.
Herein,
the
photosensitizer
rhodamine
derivatives
are
selected
as
light‐trapping
dye
electron‐rich
substituent
N‐nitrosoaminophen
nitric
oxide
(NO)‐releasing
component
develop
a
multifunctional
(deep)
red‐light
activatable
NO
photocage/photodynamic
prodrug
for
efficient
treatment
of
wounds
diabetic
foot
infections.
The
prodrug,
RhB‐NO‐2
integrates
antimicrobial
photodynamic
therapy
(aPDT),
sterilization,
NO‐mediated
anti‐inflammatory
properties
within
small
organic
molecule
is
capable
releasing
generating
Reactive
oxygen
species
(ROS)
when
exposed
red
laser
(660
nm).
This
strategy
overcomes
limitation
using
single
photosensitizer,
which
inadequate
eliminating
bacteria.
Additionally,
it
demonstrates
that
released
from
can
interact
with
superoxide
anions
(O
2
•−
)
generated
PDT
form
more
reactive
oxidative
agent,
peroxynitrite
(ONOO
−
).
These
three
components
act
synergistically
enhance
effects.
Furthermore,
inhibit
NF‐κB
pathway
regulating
expression
toll‐like
receptor
(TRL2)
tumor
necrosis
factor‐α
(TNF‐α),
thereby
alleviating
tissue
inflammation.
developed
，
has
potential
expedite
healing
superficial
infected
offer
promising
approach
treating
ulcers
(DFUs).
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: March 5, 2025
Periodontitis
is
a
chronic
inflammatory
disease
induced
by
the
microbiome,
leading
to
destruction
of
periodontal
structures
and
potentially
resulting
in
tooth
loss.
Using
local
drug
delivery
systems
as
an
adjunctive
therapy
scaling
root
planning
periodontitis
promising
strategy.
However,
this
administration
method's
effectiveness
constrained
complexity
environment.
Nanomaterials
have
demonstrated
significant
potential
antibacterial
treatment
periodontitis,
attributed
their
controllable
size,
shape,
surface
charge,
high
design
flexibility,
reactivity,
specific
area.
In
review,
we
summarize
complex
microenvironment
difficulties
explicitly
reviewing
application
strategies
nanomaterials
with
unique
properties
distinct
periodontitis.
Furthermore,
review
discusses
limitations
current
research,
proposes
feasible
solutions,
explores
prospects
for
using
context.
