International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 33
Published: Dec. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
Journal of Biological Engineering,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Feb. 5, 2025
The
rise
of
antibiotic
resistance
has
made
bacterial
infections
a
persistent
global
health
issue.
In
particular,
extracellular
polymeric
substances
(EPS)
secreted
by
bacteria
limit
the
effectiveness
conventional
antibiotics,
making
biofilm
removal
challenging.
To
address
this,
we
created
ND@PDA
nanoparticles
coating
surface
nanodiamonds
(ND)
with
polydopamine
(PDA).
These
were
then
integrated
into
polyvinyl
alcohol
to
fabricate
PVA/ND@PDA
nanofiber
scaffolds,
resulting
in
an
innovative
platform
enhanced
photothermal,
antibacterial
and
antibiofilm
properties.
Upon
exposure
near-infrared
(NIR)
light,
scaffolds
exhibited
significant
photothermal
activity,
oxidative
stress
effectively
damaging
key
components,
such
as
biofilm,
membranes,
proteins.
Additionally,
catechol
groups
PDA
provided
strong
cell
adhesion
high
biocompatibility
on
surface.
Our
research
proposes
that
not
only
addresses
antibiotic-resistant
but
also
contributes
advancements
wound
healing
therapies
enabling
controlled
action
minimal
toxicity.
JTCVS Open,
Journal Year:
2025,
Volume and Issue:
24, P. 510 - 520
Published: Jan. 20, 2025
Recipients
of
lung
transplants
experience
the
lowest
long-term
survival
among
all
solid-organ
transplant
recipients.
Airway
complications
contribute
significantly
to
morbidity
and
mortality
post-lung
may
be
driven
by
airway
devascularization
inherent
procurement
implantation
lungs.
We
studied
application
biodegradable,
nanofiber-based
thin
films
devascularized
autotransplanted
airways
mitigate
ischemia.
used
a
rat
tracheal
autotransplantation
model
that
replicates
Rats
were
divided
into
an
operated
control
group
(n
=
18)
treatment
12)
receiving
electrospun
film
composed
randomly
aligned
polydioxanone
(PDO)
nanofibers
applied
circumferential
surface
transplanted
trachea.
perfusion
was
assessed
via
laser
speckle
contrast
analysis
at
0,
3,
10
days.
Differences
in
units
calculated
between
nontransplanted
segments
Multimodal
angiogenesis
autografts
included
immunoassay
profiling
for
proangiogenic
cytokines,
histologic
injury
grading,
angiography.
Qualitative
quantitative
differences
demonstrated
days
10.
Nanofiber-based,
PDO
improved
segment
trachea
(P
<
.05).
Histologic
scoring
worse
controls
compared
with
.01).
Immunoassays
increased
expression
vascular
cell
adhesion
molecule
1
Application
nanofiber-based,
induced
local
tissue
response
autotransplant
devascularization.
Immune
multiplexing
suggests
inflammatory
responses
drive
angiogenesis.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 29, 2025
Excessive
vascularization
during
tracheal
in-stent
restenosis
(TISR)
is
a
significant
but
frequently
overlooked
issue.
We
developed
an
anti-inflammatory
coupled
anti-angiogenic
airway
stent
(PAGL)
incorporating
anlotinib
hydrochloride
and
silver
nanoparticles
using
advanced
electrospinning
technology.
PAGL
exhibited
hydrophobic
surface
properties,
exceptional
mechanical
strength,
appropriate
drug-release
kinetics.
Moreover,
it
demonstrated
remarkable
eradication
effect
against
methicillin-resistant
Staphylococcus
aureus.
It
also
displayed
anti-proliferative
properties
on
human
umbilical
vein
endothelial
cells
lung
fibroblasts.
was
implanted
into
the
tracheae
of
New
Zealand
rabbits
to
evaluate
its
efficacy
in
inhibiting
bacterial
infection,
suppressing
inflammatory
response,
reducing
angiogenesis,
attenuating
excessive
fibroblast
activation.
RNA
sequencing
analysis
revealed
downregulation
genes
associated
with
fibrosis,
intimal
hyperplasia,
cell
migration
following
treatment.
This
study
provides
insight
development
stents
that
target
angiogenesis
inflammation
address
problems
TISR
effectively
have
potential
for
clinical
translation.
Biopolymers,
Journal Year:
2025,
Volume and Issue:
116(3)
Published: April 30, 2025
ABSTRACT
This
study
focused
on
the
development
of
wound
dressings.
Plant
active
ingredients
such
as
clover,
chickweed,
chamomile,
garlic,
liverwort,
bitter
melon,
pine
resin,
marigold
(
Calendula
officinalis
),
and
St.
John's
Wort
Hypericum
perforatum
L.)
were
reinforced
with
polyethylene
oxide
(PEO)
polyvinyl
alcohol
(PVA)
polymers,
nanofiber
membranes
produced
by
electrospinning.
As
a
result
analyses,
FTIR
confirmed
presence
polymer
ingredient
functional
groups
in
composite
membranes;
softening
shifting
observed
peaks.
In
FEGSEM
analysis,
thin
regular
structure
was
obtained
S12
membrane
range
150–500
nm.
tensile
test,
strength
sample
measured
25.89
MPa,
this
associated
homogeneous
distribution
thinning
fibers.
mesenchymal
stem
cell
viability
determined
98%,
death
2%
for
at
end
72
h.
The
results
show
that
can
be
used
biomaterial
ideal
properties
healing
applications.
