International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 33
Published: Dec. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
Micro,
Journal Year:
2024,
Volume and Issue:
4(4), P. 599 - 620
Published: Oct. 28, 2024
This
study
investigated
the
development
of
Pullulan/Collagen
nanofiber
scaffolds
integrated
with
mesenchymal
stem
cells
(MSCs)
to
enhance
chronic
wound
healing.
The
combination
these
biopolymers
aims
optimize
scaffold
properties
for
cell
growth,
viability,
and
tissue
regeneration.
Materials
Methods:
Pullulan,
Collagen,
composite
nanofibers
were
fabricated
using
electrospinning.
fibers
characterized
scanning
electron
microscopy
(SEM)
determine
fiber
diameter,
Fourier-transform
infrared
spectroscopy
(FTIR)
was
employed
assess
molecular
interactions.
Cell
viability
evaluated
MSCs
cultured
on
apoptosis
assays
conducted
health.
Distilled
water
used
as
solvent
maximize
biocompatibility.
Results:
SEM
analysis
revealed
that
Pullulan
exhibited
a
larger
average
diameter
(274
±
20
nm)
compared
Collagen
(167.03
40.04
nm),
while
averaged
280
102
nm.
FTIR
confirmed
interactions
between
Collagen.
Regarding
biocompatibility,
demonstrated
superior
at
99%
91%
alone.
Apoptosis
indicated
significantly
lower
necrosis
rates
(1.29%)
than
Pullulan-only
(2.35%).
Conclusion:
use
distilled
played
critical
role
in
increasing
facilitating
healthy
proliferation
without
cellular
damage.
Additionally,
reduced
platelet
activation
macrophage
activity
(0.75-fold
both)
further
supported
biocompatibility
scaffold,
demonstrating
its
potential
engineering
healing
applications.
Vrach,
Journal Year:
2024,
Volume and Issue:
unknown, P. 27 - 29
Published: Oct. 1, 2024
In
recent
years,
bioplastic
collagen
based
materials
have
become
widespread
in
reconstructive
surgery
due
to
their
unique
biological
and
mechanical
properties.
The
article
reviews
modern
advances
the
development
application
of
biomaterials
for
soft
tissue,
bone
cartilage
repair,
as
well
effectiveness
comparison
with
other
types
used
rehabilitation.
Special
attention
is
paid
improvement
properties
chemical
modification,
crosslinking
combination
synthetic
polymers,
which
allows
increasing
biocompatibility,
resistance
degradation
strength.
key
applications
materials,
including
chronic
wound
healing,
repair
osteoarthritis,
regeneration
after
trauma
surgery.
A
comparative
analysis
alternative
such
polymers
ceramics
has
been
performed.
It
shown
that
are
superior
analogs
terms
biocompatibility
ability
stimulate
cell
proliferation,
but
combined
on
show
best
results
stability
bioactivity.
presented
data
indicate
a
high
potential
use
surgery,
emphasize
need
further
research
optimize
expand
clinical
practice.
International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 33
Published: Dec. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
