Analyze interleukin-1β, interleukin-6, and tumor necrosis factor-α levels in dry eye and the therapeutic effect of cyclosporine A

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(25), P. 5665 - 5672

Published: July 12, 2024

Dry eye is a common disease. Artificial tears supplements are widely used for the treatment of dry eyes. However, multiple adverse effects have been observed in patients receiving long-term with artificial tears, which may affect therapeutic effect.

Language: Английский

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Multicomponent Dietary Supplementation: Impact on Tear Secretion and Ocular Surface Inflammation in Dry Eye Syndrome Patients

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 103 - 103

Published: Jan. 16, 2025

Dry eye syndrome (DES) is a prevalent ocular condition characterized by tear film instability, inflammation, and discomfort, affecting millions worldwide. DES related to oxidative stress imbalance surface which are important factors in the development of condition. Recent studies have demonstrated that fish oil, lutein, zeaxanthin possess anti-inflammatory antioxidant properties. This study investigated efficacy multicomponent dietary supplement improving secretion mitigating inflammation patients with DES. It was an open-label intervention trial. In total, 52 participants were randomly assigned control (n = 23) (45 mg/day eicosapentaenoic acid, 30 docosahexaenoic 1.8 zeaxanthin; n 29) groups for 12 weeks. The evaluated using Schirmer's test disease index (OSDI) as parameters. Moreover, blood or stress, capacities, inflammatory indicators measured at weeks 0 12. results indicated significant increase reduction OSDI scores group. Additionally, markers, such interleukin (IL)-6 IL-8, significantly decreased after intervention. However, group improved 6.60 points (β -6.60, p 0.01). These findings support potential targeted nutritional supplementation safe effective strategy alleviating symptoms, offering alternative conventional treatments exclusively focus on symptom management. highlights role specific nutrients modulating production thereby providing foundation approaches treatment. Future research should explore long-term benefits interventions their impact overall health.

Language: Английский

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Engineering biocompatible carbon dots nano-enzymes hydrogel for efficient antioxidative and anti-inflammatory treatment of dry eye disease

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113490 - 113490

Published: March 10, 2025

Language: Английский

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Advances in the application of smart materials in the treatment of ophthalmic diseases

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123316 - 123316

Published: April 1, 2025

Language: Английский

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Aminated Fullerene for Comprehensive Dry Eye Therapy: Promoting Epithelial-Barrier Reconstruction and Nerve Regeneration by Suppressing Oxidation and Inflammation

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123329 - 123329

Published: April 1, 2025

Language: Английский

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Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants

Global Challenges, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Dry eye disease (DED), a multifactorial ocular surface disorder characterized by tear film instability, is pathologically linked to oxidative damage. The accumulation of reactive oxygen species (ROS) across tissues not only directly damages nucleic acids, proteins, and lipids, but also functions as an upstream driver inflammation hyperosmolarity, collectively disrupting cellular homeostasis. This review comprehensively delineates the mechanistic interplay between stress (OS) DED pathogenesis, synthesizing evidence on enzymatic/ nonenzymatic antioxidant alterations in samples corneal, lacrimal, conjunctival, meibomian gland, tissues, alongside quantitative profiling OS biomarkers, such 4‐hydroxynonenal (4HNE), malondialdehyde (MDA), 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), 3‐nitrotyrosine (3‐NT). Furthermore, therapeutic mechanisms clinically approved investigational antioxidants, including SKQ1, rebamipide, mitoquinone, elamipretide, lactoferrin, nanozymes, graphene quantum dots, tetrahedral frame Chinese medicine monomers are critically evaluated. With changes modern social environment lifestyle, influence gradually expanding. Antioxidant‐based interventions poised become cornerstone components multimodal management strategies.

Language: Английский

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Revolutionizing Retinal Therapy: The Role of Nanoparticle Drug Carriers in Managing Vascular Retinal Disorders

Clinical ophthalmology, Journal Year: 2025, Volume and Issue: Volume 19, P. 1565 - 1582

Published: May 1, 2025

Vascular Retinopathy (VR), such as diabetic retinopathy, pose significant challenges to vision and overall health. Traditional treatment methods often face limitations in efficacy delivery. retinopathy is a common potentially blinding group of eye diseases with core pathologic mechanisms involving vascular injury, ischemia, exudation, neovascularization. Clinical management relies heavily on etiologic control (eg, diabetes, hypertension), anti-VEGF therapy, laser surgical intervention. Recent advancements nanotechnology have led the development innovative nanoparticle drug carriers, which offer promising solutions for targeted sustained delivery retinal environment. This review explores application both conventional novel carriers treating VR. We discuss various types nanoparticles, including liposomes, polymeric metal-based highlighting their unique properties, action, therapeutic benefits. Finally, we provide insights into future perspectives nanoparticle-based therapies disorders, emphasizing potential improved patient outcomes need further research optimize these advanced systems.

Language: Английский

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Dual-Stabilized Selenium Nanoparticles with Chitosan and SS31 Peptide: Resolving instability for enhancing ROS elimination, suppressing inflammation, and combating bacterial infections

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114749 - 114749

Published: May 1, 2025

Language: Английский

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Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract The incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have unable address all harmful factors and fail achieve a complete clinical cure. Ferroptosis, form programmed cell death characterized by lipid peroxidation, become pivotal contributor oxidative stress‐driven pathology. Therefore, therapeutic targeting ferroptosis may be attractive option management. Herein, sialic acid‐targeting peptide‐modified liposome loaded with Cyclosporine A (CsA), typical anti‐inflammatory drug, Ferrostatin‐1 (Fer‐1), selective inhibitor, is developed termed as CF@SNPs, combing sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, peptide prolongs retention, further enhancing efficacy. CF@SNPs treatment comprehensively alleviates symptoms, including improving corneal defects, augmenting goblet count, restoring tear secretion. Specifically, attenuate pathology suppressing p53‐SLC7A11‐GSH‐dependent TNF‐α‐associated inflammatory cascades, accompanied favorable biocompatibility in vivo. These results underscore promising potential this superior nano‐formulation pharmacotherapy.

Language: Английский

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Global research hotspots and trends in anti-inflammatory studies in dry eye: a bibliometric analysis (2004–2024)

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 28, 2024

Inflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide comprehensive overview current status, hotspots and trends DE anti-inflammatory research through bibliometric analysis.

Language: Английский

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