Nanobody-as Versatile Tool Emerging in Autoimmune Diseases DOI Creative Commons
Ling Wang, Ran Luo,

Wenkang Zhang

et al.

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Nectin-4-directed antibody-drug conjugates (ADCs): Spotlight on preclinical and clinical evidence DOI

Mohammad Javad Khosravanian,

Yousef Mirzaei,

Ali Hussein Mer

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122910 - 122910

Published: Sept. 1, 2024

Language: Английский

Citations

9
Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines DOI Creative Commons

Liudmyla Maksymova,

Yannick A. Pilger,

Lutz Nuhn

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 4, 2025

Among the emerging strategies for cancer theranostics, nanomedicines offer significant promise in advancing both patients' diagnosis and treatment. In combination with nanobodies, can potentially enhance precision efficiency of drug or imaging agent delivery, addressing key limitations current approaches, such as off-target toxicities. The development will be further accelerated by creation smart nanoparticles, their integration immunotherapy. Obviously, success nano-immunotherapy depend on a comprehensive understanding tumor microenvironment, including complex interplay mechanisms that drive cancer-mediated immunosuppression immune escape. Hence, effective therapeutic targeting microenvironment requires modulation cell function, overcoming resistance associated stromal components extracellular matrix, and/or direct elimination cells. Identifying molecules involved progression is, therefore, essential developing therapies diagnostic tools predict patient responses to treatment monitor outcomes. Current are being designed careful consideration factors choice carrier (e.g., biocompatibility, controlled cargo release) moiety. unique properties nanobodies make them an engineering tool target biological high affinity specificity. this review, we focus latest applications various purposes. We also explore main types nanoparticles used immunotherapies, well formulating nanoparticle-nanobody conjugates. Finally, highlight how nanobody-nanoparticle formulations nanomedicines.

Language: Английский

Citations

1
Nanobody-based drug delivery systems for cancer therapy DOI
Lin Liu, Bin Tu, Yao Sun

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113562 - 113562

Published: Feb. 22, 2025

Language: Английский

Citations

0
Theranostic Implications of Nectin-4 Oncoprotein in Gynecologic Cancers: A Review DOI

Olivia Hooks,

Yash Nagpal,

Justin T Childers

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155913 - 155913

Published: March 15, 2025

Language: Английский

Citations

0
Navigating the future of gastric cancer treatment: a review on the impact of antibody-drug conjugates DOI Creative Commons
Qian-Qing Yin, Yanlong Zhang,

Xueqing Xie

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 5, 2025

Abstract Gastric cancer, marked by its high incidence and poor prognosis, demands the urgent development of novel effective treatment strategies, especially for patients ineligible surgery or those who have had limited success with chemotherapy, radiotherapy targeted therapies. Recently, antibody-drug conjugates (ADCs) become a key area investigation due to their specificity potent antitumor effects. These therapies combine monoclonal antibodies, designed bind tumor-specific antigens, cytotoxic agents that selectively target destroy malignant cells. ADCs generated significant interest in clinical trials as promising approach improve both efficacy patient outcomes gastric cancer. However, application is not without challenges limitations must be addressed. This review discusses recent progress use cancer treatment.

Language: Английский

Citations

0
Site-specific tethering nanobodies on recombinant adeno-associated virus vectors for retargeted gene therapy DOI

Yuanjie Zhang,

Zhiqian Chen,

Xiaoyang Wang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 304 - 315

Published: July 16, 2024

Language: Английский

Citations

2
Nanobody-as Versatile Tool Emerging in Autoimmune Diseases DOI Creative Commons
Ling Wang, Ran Luo,

Wenkang Zhang

et al.

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1