Enzyme-Instructed Self-assembled Supramolecular Bi-Antibodies for Inhibition and Imaging of Atherosclerosis Progression DOI Creative Commons

Shuang Bian,

Yanyan Zhu,

Ninglin Zhao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101827 - 101827

Published: May 1, 2025

Language: Английский

Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque DOI Creative Commons
Yuwu Chen,

Biyi Xu,

Quan Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to progression atherosclerosis (AS). Meanwhile, Spermine (Sp) serve as an endogenous small molecule exhibiting a wide range cardiovascular protective effects. Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were synthesized and utilized create novel delivery nanosystem encapsulated with Sp (CD16/32-ZIF90@Sp). The efficacy CD16/32-ZIF90@Sp in protecting against AS was evaluated ApoE-/- mice macrophages, focus on assessing potential adverse effects vivo. exhibited reliable stable within acidic environments ATP sensitivity. effectively reduced cytotoxicity Sp. As is evidenced by vitro vivo experiments, showed precise targeting atherosclerotic plaques ox-LDL-activated macrophages. Furthermore, treatment attenuated macrophage plaque without causing significant side Mechanistically, we found inhibited via improving mitochondrial function upregulating expression level GPX4/xCT. Our study demonstrated CD16/32-modified ZIF90 target plaques, leading inhibition mice. These attributed enhancement ferroptosis, limited

Language: Английский

Citations

2
High-density lipoprotein-based nanoplatforms for macrophage-targeted diagnosis and therapy of atherosclerosis DOI

Jianhua He,

Yu Dai,

Fengfei Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140826 - 140826

Published: Feb. 1, 2025

Language: Английский

Citations

0
Biomimetic high-density lipoproteins for cardiovascular diseases DOI
Dipak Gadade, Deepak Kulkarni, Anuj Modi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 69 - 95

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeted drug delivery systems for atherosclerosis DOI Creative Commons
Liangxing Tu,

Zijian Zou,

Yang Ye

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management

Language: Английский

Citations

0
Enzyme-Instructed Self-assembled Supramolecular Bi-Antibodies for Inhibition and Imaging of Atherosclerosis Progression DOI Creative Commons

Shuang Bian,

Yanyan Zhu,

Ninglin Zhao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101827 - 101827

Published: May 1, 2025

Language: Английский

Citations

0