Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104641 - 104641

Published: Dec. 5, 2024

Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced (IM) in aged hens improve their egg- performance. Jejunal lipophagy lipid metabolism data were analyzed elucidate regulatory mechanisms by which intestine affects egg production performance, particularly through lens digestion absorption processes. Molting facilitated regeneration small intestinal villi following damage shedding, while also reducing excess accumulation within intestine. Analyses metabolism-related factors revealed, increased expression levels genes proteins, such as AMPK, FOXO1, TFEB, TFE3, PGC-1α PPAR-α (P<0.05, P<0.01 P<0.001). Serological analysis detection enzymes involved absorption, showed upregulated GLUT2, FABP (P<0.05 P<0.001) CD36 (P<0.01), activities amylase, chymotrypsin Lipase significantly conclusion, artificially IM activates AMPK-lipophagy-lipid pathway enhance Our findings offer theoretical framework for intentional use promote healthy state absorption.

Language: Английский

The recent development, application, and future prospects of muscle atrophy animal models

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский