Pancreas Pyroptosis and Self-Digestion Inhibitions by Multi-Enzymically Catalytic Nanoeffectors Reject Death-Sentenced Acute Pancreatitis DOI Creative Commons

Xiulin Dong,

Sijia Hua,

Kun Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Acute pancreatitis (AP) is associated with a high mortality rate, and thereby AP therapy still challenge. Pancreatic enzymes overproduction-induced pancreas self-digestion persistent oxidative stress-associated pyroptosis have been identified two root causes against current therapy. Herein, single-atom nanozymes of Co-based SAE (Co-SAE) inherent antioxidant surface modified trypsin activity inhibitor Rhamnetin (Rh) are developed to inhibit the progression AP. It found that in mouse model, this formulation (Rh@SAE) confers effective protection self-digestion, stress, inflammatory cell infiltration, tissue damage. Importantly, death pancreatic acinar cells (PACs) alleviated as validated by blockade GSDMG cleavage, inactivation caspase 1, reduction release cytokines (IL-1𝛽) lactate dehydrogenase (LDH). Overall, work possesses huge potential for improving outcomes, which opens new catalytic avenue

Language: Английский

Catalytic activity nanozymes for microbial detection DOI
Zhengyu Jin, Guodong Huang, Yang Song

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216578 - 216578

Published: March 4, 2025

Language: Английский

Citations

0
Preparation and application of single-atom nanozymes in oncology: a review DOI Creative Commons

Huiyuan Liang,

Yijie Xian,

Xujing Wang

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 12, 2024

Single-atom nanozymes (SAzymes) represent a cutting-edge advancement in nanomaterials, merging the high catalytic efficiency of natural enzymes with benefits atomic economy. Traditionally, exhibit specificity and efficiency, but their stability are limited by environmental conditions production costs. Here we show that SAzymes, large specific surface area utilization, achieve superior activity. However, dispersibility poses challenges. Our review focuses on recent structural preparative advancements aimed at enhancing SAzymes. Compared to previous nanozymes, SAzymes demonstrate significantly improved performance biomedical applications, particularly tumor medicine. This progress positions as promising tool for future cancer treatment strategies, integrating robustness inorganic materials biological systems. The development application could revolutionize field biocatalysis, offering stable, cost-effective alternative enzymes.

Language: Английский

Citations

2
POMCPs/g-C3N4 composite material as peroxidase mimics for colorimetric sensing DOI

Qiao-Ming Liang,

Jian Liu,

Yue-Xiao Liu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1320, P. 139777 - 139777

Published: Aug. 24, 2024

Citations

0
Pancreas Pyroptosis and Self-Digestion Inhibitions by Multi-Enzymically Catalytic Nanoeffectors Reject Death-Sentenced Acute Pancreatitis DOI Creative Commons

Xiulin Dong,

Sijia Hua,

Kun Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Acute pancreatitis (AP) is associated with a high mortality rate, and thereby AP therapy still challenge. Pancreatic enzymes overproduction-induced pancreas self-digestion persistent oxidative stress-associated pyroptosis have been identified two root causes against current therapy. Herein, single-atom nanozymes of Co-based SAE (Co-SAE) inherent antioxidant surface modified trypsin activity inhibitor Rhamnetin (Rh) are developed to inhibit the progression AP. It found that in mouse model, this formulation (Rh@SAE) confers effective protection self-digestion, stress, inflammatory cell infiltration, tissue damage. Importantly, death pancreatic acinar cells (PACs) alleviated as validated by blockade GSDMG cleavage, inactivation caspase 1, reduction release cytokines (IL-1𝛽) lactate dehydrogenase (LDH). Overall, work possesses huge potential for improving outcomes, which opens new catalytic avenue

Language: Английский

Citations

0