Apolipoprotein E as a Potential Regulator of Osteoclast-Osteoblast Coupling in Material-Induced Bone Formation DOI
Yue Wang, Zhangling Nie,

H. B. Liu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

“Potential of Baobab (Adansonia digitata L.) Dried Fruit Pulp in Contributing to Food and Nutrient Security in Sudan and Senegal” DOI Creative Commons
Abdelhakam Esmaeil Mohamed Ahmed, Massimo Mozzon, Abdaljbbar B. A. Dawod

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101681 - 101681

Published: Jan. 1, 2025

Language: Английский

Citations

1
Multiscale Metal-based Nanocomposites for Bone and Joint Disease Therapies DOI Creative Commons
Yuwen Wang,

Hasnain Jan,

Zhong Zheng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101773 - 101773

Published: April 17, 2025

Bone and joint diseases are debilitating conditions that can result in significant functional impairment or even permanent disability. Multiscale metal-based nanocomposites, which integrate hierarchical structures ranging from the nanoscale to macroscale, have emerged as a promising solution this challenge. These materials combine unique properties of nanoparticles (MNPs), such enzyme-like activities, stimuli responsiveness, photothermal conversion, with advanced manufacturing techniques, 3D printing biohybrid systems. The integration MNPs within polymer ceramic matrices offers degree control over mechanical strength, antimicrobial efficacy, manner drug delivery, whilst concomitantly promoting processes osteogenesis chondrogenesis. This review highlights breakthroughs stimulus-responsive (e.g., photo-, magnetically-, pH-activated systems) for on-demand therapy their biocomposite hybrids containing cells extracellular vesicles mimic native tissue microenvironment. applications these composites extensive, bone defects, infections, tumors, degenerative diseases. emphasizes enhanced load-bearing capacity, bioactivity, be achieved through designs. Notwithstanding potential applications, barriers progress persist, including challenges related long-term biocompatibility, regulatory hurdles, scalable manufacturing. Finally, we propose future directions, machine learning-guided design patient-specific biomanufacturing accelerate clinical translation. bridge innovations macroscale functionality, revolutionary force field biomedical engineering, providing personalized regenerative solutions

Language: Английский

Citations

1
Quantitative Analysis of Salmon Calcitonin Hydroxyapatite Nanoparticle Permeation to substantiate Non-Invasive Bone Targeting via Sublingual Delivery DOI

Darsheen J. Kotak,

Esha S. Attar,

Bhavik Dalal

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: March 18, 2025

Language: Английский

Citations

0
Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis DOI Creative Commons
M. Shi,

Feng Jin,

Ping Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Osteoporosis, a condition marked by reduced bone mass and structural deterioration, continues to be major public health concern, especially as global populations age. Excessive osteoclast formation is hallmark of osteoporosis. The transcription factor nuclear activated T-cells cytoplasmic 1 (NFATc1) indispensable for the early differentiation osteoclasts, orchestrating expression essential genes, while at later stages, cathepsin K (CTSK) resorption activities mature osteoclasts. Here, we fabricated ultrasound-responsive microdroplets (MDs) modulating both stages functions osteoclasts via targeting NFATc1 CTSK. internalization these dual MDs was evaluated in human marrow-derived mesenchymal stromal cells (hBMSCs) murine RAW 264.7 macrophages, alongside biocompatibility assay. Their effects on osteogenesis osteoclastogenesis were further investigated vitro, followed vivo analysis osteoporotic rat models. exhibited well-defined core-shell structure demonstrated efficient cellular uptake with minimal cytotoxicity. Furthermore, showed effect osteogenic hBMSCs. In vitro assays, effectively suppressed through synergistic inhibitory effect. studies that rats receiving significant protection against loss induced ovariectomy. These results highlight potential sophisticated, targeted therapeutic approach osteoporosis treatment.

Language: Английский

Citations

0
Triple-effect strategy with taxifolin-whitlockite nanoparticles embedded hydrogel for osteoporotic bone defect repair and bone homeostasis modulation DOI Creative Commons
Jiawei Jiang, Cong Cai, Song Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163133 - 163133

Published: May 1, 2025

Language: Английский

Citations

0
Multi-crosslinked network magnesium phosphate bone cement with high flexural properties DOI
Zijie Gao, Jiawei Liu, Mingjiang Zhang

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Apolipoprotein E as a Potential Regulator of Osteoclast-Osteoblast Coupling in Material-Induced Bone Formation DOI
Yue Wang, Zhangling Nie,

H. B. Liu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0