Exploring the Roles and Clinical Potential of Exosome-Derived Non-Coding RNAs in Glioma

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 323 - 337

Published: Feb. 6, 2025

Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved cancer development development. RNAs are abundantly enriched exosomes, which play a biological role as vectors. Some biofunctional non-coding specifically designed exosomes treatment cancers such glioma. Glioma is one most common primary tumors within skull has varying degrees malignancy histologic subtypes grades I-IV. Gliomas characterized by high an abundant blood supply due to rapid cell proliferation vascularization, often with poor prognosis. Exosomal can be tumorigenesis process glioma from multiple directions, angiogenesis, tumor proliferation, metastatic invasion, immune evasion, apoptosis, autophagy. Therefore, suitable markers or therapeutic targets early diagnosis diseases predicting prognosis variety diseases. Regulating exosome production level exosomal RNA expression may new approach prevent eliminate In this review, we review origin characteristics RNAs, introduce functional studies their potential clinical applications, order broaden ideas

Language: Английский

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Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review summarizes naïve extracellular vesicles (EVs) in clinical trials for central nervous system (CNS) diseases and updates recent translational preclinical research on EV-loaded drugs or genes CNS treatments.

Language: Английский

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Tumor cell-derived engineered exosome enhances effective immunotherapy for orthotopic glioblastoma and its recurrences

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102748 - 102748

Published: April 8, 2025

Language: Английский

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Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117553 - 117553

Published: Oct. 13, 2024

Language: Английский

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Implications of glioblastoma-derived exosomes in modifying the immune system: state-of-the-art and challenges

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Glioblastoma is a brain cancer with poor prognosis. Failure of classical chemotherapy and surgical treatments indicates that new therapeutic approaches are needed. Among cell-free options, exosomes versatile extracellular vesicles (EVs) carry important cargo across barriers such as the blood-brain barrier (BBB) to their target cells. This makes an interesting option for treatment glioblastoma. Moreover, can comprise many cargos, including lipids, proteins, nucleic acids, sampled from special intercellular compartments origin cell. Cells exposed various immunomodulatory stimuli generate enriched in specific molecules. Notably, secretion could modify immune response innate adaptive systems. For instance, glioblastoma-associated (GBex) uptake by macrophages influence macrophage dynamics (e.g., shifting CD markers expression). Expression critical immunoregulatory proteins cytotoxic T-lymphocyte antigen-1 (CTLA1) programmed death-1 (PD-1) on GBex direct crosstalk these nano-size system. The present study reviews role system cells, B T natural killer (NK) dendritic cells (DCs), well novel technologies field.

Language: Английский

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A detailed evaluation of the advantages among extracellular vesicles from three cell origins for targeting delivery of celastrol and treatment of glioblastoma

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125005 - 125005

Published: Nov. 1, 2024

Language: Английский

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