Electrosprayed core–shell microspheres co-deliver fibronectin and resveratrol for combined treatment of acute lung injury

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 686, P. 498 - 508

Published: Jan. 31, 2025

Language: Английский

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Mannose-modified exosomes loaded with MiR-23b-3p target alveolar macrophages to alleviate acute lung injury in Sepsis

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 832 - 847

Published: Jan. 29, 2025

Language: Английский

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Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 20, 2025

Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through anti-inflammatory and cytoprotective effects, their age-related functional decline limits utility. This study developed chitosan-functionalized selenium nanoparticles (SeNPs@CS, 100 nm) to rejuvenate BMSCs miR-20b-mediated selenoprotein biosynthesis. Mechanistic investigations revealed that SeNPs@CS-treated exhibited enhanced mitochondrial transfer capacity, delivering mitochondria damaged alveolar epithelial (AECII) for cellular repair. Concurrently, miR-20b upregulation suppressed the RORγt/STAT3/Th17 axis, reducing pro-inflammatory Th17 cell differentiation in CD4+ T lymphocytes. The dual-target mechanism integrates immunomodulation via pathway inhibition rejuvenation therapy, representing paradigm-shifting approach ALI management. These engineered mitigated markers murine models, demonstrating superior efficacy conventional BMSC therapies. Our findings establish SeNPs@CS-modified as novel platform combining nanotechnology-enhanced engineering precision immunometabolic regulation, providing new avenues treatment of sepsis-induced ALI.

Language: Английский

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Nanodrug Delivery System for Precision Treatment of Pulmonary Fibrosis

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100025 - 100025

Published: March 1, 2025

Language: Английский

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Extracellular vesicles from adipose-derived mesenchymal stem cells alleviate acute lung injury via the CBL/AMPK signaling pathway

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 31, 2025

Acute lung injury (ALI) which is caused by Staphylococcus aureus (SA), a serious disease that threatens human health. Although some current treatments are effective in alleviating ALI, they still have significant mortality rate. At present, adipose-derived mesenchymal stem cells (ADSCs)-derived extracellular vesicles (EVs) been investigated for the treatment of various diseases. Here, we examined role ADSCs-derived EVs regulating apoptosis and inflammation during ALI. We showed ADSCs supplementation could improve injury, restore mitochondrial function, inhibit ALI mice. Furthermore, miR-320a was present derived from ADSCs, it can be transferred into tissue. In vitro, Casitas B-lineage lymphoma (CBL) expression inhibited mimics. Finally, found alleviated damage, inflammation, via CBL/AMPK/JNK pathway. conclusion, alleviate CBL/AMPK signaling Therefore, purpose our study to investigate application ADSC-derived mitigating modulating metabolic processes.

Language: Английский

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Waste tobacco leaf-driven carbon dot nanozymes with high reactive oxygen species scavenging and anti-inflammatory activities for the amelioration of acute lung injury

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 229, P. 120958 - 120958

Published: April 17, 2025

Language: Английский

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Physicochemical Dual Cross-Linked Multifunctional Conductive Organohydrogel Sensors for Fireworks Burn Wound Healing and Intelligent Real-Time Monitoring

Polymer science & technology., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Conductive hydrogels have garnered significant attention in the realm of future flexible electronic devices due to their properties such as flexibility, electrical conductivity, frost resistance, and biocompatibility. However, integration numerous functional applications biomedical field still presents notable challenges. In this research, a rigid hard-structured network was formed by cross-linking gallic acid grafted chitosan (CS–GA) tannic (TA) with poly(vinyl alcohol) (PVA) through physical freezing. The noncovalent hydrogen bonding during freezing thawing process facilitated formation microcrystalline domains amorphous hydrogel system. Functional proteins from eggshell membrane were cross-linked tetra-armed poly(ethylene glycol) maleimide (4am-PEG-MAL) via thiol-olefin click chemistry, lysozyme incorporated into an antibacterial component nucleophilic substitution reaction. These chemical methods resulted soft-structured that enhanced mechanical (maximum stress 2.15 MPa elongation 605%). use ionic liquids/ethylene glycol/water (ILs/EG/H2O) ternary solvents instead single solvent not only provided resistance but also imparted excellent conductivity (0.37 ± 0.04 S/m). Notably, organohydrogel showed good antimicrobial biocompatibility effective providing emergency cooling after fireworks burns promoting wet healing broken skin minimize scarring. field, multifunctional can serve wearable device monitor movement amplitude wounds real-time, offering novel approach deep learning-assisted wound healing. nature biological promising applications.

Language: Английский

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Biocompatible Metal‐Organic Framework‐Based Fabric Composite as an Efficient Personal Protective Equipment for Particulate Matter‐Induced Pulmonary Injury

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Oct. 29, 2024

Efficient personal protection has emerged as a crucial approach for reducing pulmonary injury induced by particulate matter (PM). However, current protective equipments usually lack essential biosafety concerns and fail to own adsorbing/antioxidant/antibacterial function together, making it challenge develop an integrated platform with the above characteristics. Herein, facile oxygen-free hydrothermal strategy is proposed synthesize new copper-based metal-organic frameworks, Cu-HHTPs, (HHTP: 2,3,6,7,10,11-hexahydroxytriphenylene), great activity high biosafety. The Cu-HHTPs can serve efficient additive incorporated various fabrics including cellulose acetate (CA) membrane achieve novel fabric composites, such CA@Cu-HHTPs, ideal scavenging outcome main components of PM. Evidenced animal experiments, CA@Cu-HHTPs highly mitigate PM-induced adverse effects via adsorbing PM, ROS, killing bacteria, leading significant reduction in lung permeability, inflammation oxidative stress, infection. Last but not least, two-week exposure exhibits no obvious damage toward animals examining their long-term toxicity. Collectively, this study only highlights potential attractive additives preparation also lays out concept development new-generation multifunctional equipment against

Language: Английский

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Advancements and trends in nanomaterial development for acute respiratory distress syndrome

Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Exosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

The unique properties of exosomes and their applications in ALI, particularly the delivery diverse drug molecules, are summarized. Additionally, current challenges use treatment ALI proposed.

Language: Английский

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