Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy DOI
Ruchı Tıwarı, Dhruv Dev, Maharshi Thalla

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Nov. 26, 2024

The combination of pharmacogenomics and nanotechnology science into a highly advanced single entity has given birth to personalized medicine known as nano-enabled pharmacogenomics. This review article covers all aspects starting from gene editing tools, how these have evolved or are likely be for pharmacogenomic application, can delivered using nanoparticle delivery systems. In this prior work, we explore the evolution over years, well new achievements in field genomic sciences, challenges drug creation, application strategy medicine. Particular attention is paid helps avoid problems that accompanied development earlier, example, question resistance targeted delivery. We also latest developments pharmacogenomics, such coupling with other nanobio-technologies, artificial intelligence, machine learning ethical regulatory developing technologies. possible uses improving chances pated treating drug-resistant cancers exemplified by case studies together current clinical nanotechnology. last section, discuss future trends research prospects dynamically growing area, stressing importance further advancements collaborations which will advance their maximum potential.

Language: Английский

Exosomes-based Therapeutics in Dermatology DOI Creative Commons
Lanjie Lei,

Shaoyu Zhou,

Lingyao Zeng

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Exosomes (Exos) are tiny extracellular vesicles containing a variety of active biomolecules that play important parts in intercellular communication and influence the functions target cells. The potential Exos treatment dermatological diseases has recently been well appreciated. This review highlights constituents, function, delivery Exos, with particular focus on their applications skin therapy. Firstly, we offer concise overview biochemical properties including sources, structures, internal constituents. Subsequently, biomedical latest advances extraction purification summarized. We further discuss modes underscore biomaterials this regard. Finally, summarize application Exo-aided therapy dermatology. Overall, objective is to provide comprehensive perspective recent advancements Exo-based approaches treating diseases, intention guiding future research efforts.

Language: Английский

Citations

0
Harnessing Synthetic Biology for Sustainable Industrial Innovation: Advances, Challenges, and Future Direction DOI
Emmanuel Chimeh Ezeako, Barine Innocent Nwiloh,

Malachy Chigozie Odo

et al.

Biochemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 109777 - 109777

Published: May 1, 2025

Language: Английский

Citations

0
Toxicity Evaluation of Sulfobetainized Branched Polyethyleneimine via Antibacterial and Biocompatibility Assays DOI Creative Commons
Mehtap Sahiner, Selin Sagbas, Şahin Demirci

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 136 - 136

Published: Feb. 14, 2025

Branched polyethyleneimine (PEI), possessing different types of amines-e.g., primary, secondary, and tertiary-in the polymer chains are well known for their antibacterial properties DNA condensing ability, affording substantial advantages in many biomedical uses, including gene therapy. However, because PEI's toxicity, depending on molecular weight, its widespread use is hindered. Therefore, this study, PEIs with weights-i.e., 600, 1200, 1800 g/mol-were modified 1,3-propane sultone, undergoing a sulfobetainization reaction single step to attain zwitterionic structure: sulfobetainized PEI (b-PEI). The was carried out twice increase repeating unit chains. increasing number SO3- groups confirmed by increased peak intensities around 1160 1035 cm-1 FT-IR spectrum, which assigned symmetric asymmetric S=O peaks. elemental analysis results first- second- betainization PEIs, abbreviated as b1-PEI b2-PEI, respectively, were revealedthe wt% S confirming successful multiple-sulfobetainization Thermal stability analyses corresponding multiple-sulfobetainized forms showed that reactions thermal bare lower weights exhibited more antimicrobial properties. As sulfobetainated, can be further adjusted via (once or twice), adjusting solution pH, protonating them acids counter anions. cell toxicity L929 fibroblast cells slightly weight PEI, but all found safe (no toxicity), even at 1000 µg/mL concentrations.

Language: Английский

Citations

0
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials DOI Creative Commons
Qian Cai, Rui Guo, Dafu Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Language: Английский

Citations

0
Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy DOI
Ruchı Tıwarı, Dhruv Dev, Maharshi Thalla

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Nov. 26, 2024

The combination of pharmacogenomics and nanotechnology science into a highly advanced single entity has given birth to personalized medicine known as nano-enabled pharmacogenomics. This review article covers all aspects starting from gene editing tools, how these have evolved or are likely be for pharmacogenomic application, can delivered using nanoparticle delivery systems. In this prior work, we explore the evolution over years, well new achievements in field genomic sciences, challenges drug creation, application strategy medicine. Particular attention is paid helps avoid problems that accompanied development earlier, example, question resistance targeted delivery. We also latest developments pharmacogenomics, such coupling with other nanobio-technologies, artificial intelligence, machine learning ethical regulatory developing technologies. possible uses improving chances pated treating drug-resistant cancers exemplified by case studies together current clinical nanotechnology. last section, discuss future trends research prospects dynamically growing area, stressing importance further advancements collaborations which will advance their maximum potential.

Language: Английский

Citations

0