Simultaneous Quantification of Bioactive Triterpene Saponins Calenduloside E and Chikusetsusaponin IVa in Different Plant Parts of Ten Amaranthaceae Species by UPLC-ESI-MS/MS Method

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1088 - 1088

Published: Feb. 27, 2025

Calenduloside E (CE) and chikusetsusaponin IVa (ChIVa) are triterpene saponins with multidirectional bioactivity. In this study, the contents of CE ChIVa were determined in roots, stems, leaves, fruits ten wild-growing species Amaranthaceae. To achieve optimal extraction conditions for both saponins, maceration, shaking-assisted ultrasound-assisted heat reflux compared. A sensitive, specific, rapid UPLC-MS/MS method was developed validated simultaneous quantification ChIVa. The results showed that coexisted most analyzed, except Ch. hybridum. For first time, presence noted L. polysperma, A. patula, B. bonus-henricus, O. rubra, glauca. Of highest content found fruit sagittata (13.15 mg/g dw), polysperma (12.20 album (10.0 roots strictum (5.52 7.77 dw, respectively). amount (7.84 dw) (6.54 dw). These saponin-abundant plant parts Amaranthaceae spp. may be considered convenient sources these bioactive saponins.

Language: Английский

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Introduction to Nanoparticles in Neurology

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Jan. 1, 2025

Language: Английский

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Neurological Emergency Treatment Strategy: A Neuron-Targeted Regulation System for Reactive Oxygen Species Metabolism through Ferroptosis Modulation

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Spinal cord injury (SCI) represents a significant clinical challenge. Following SCI, the implementation of protective measures for neurons is critically important. Current applications hormone pulse therapy exhibit variable efficacy and considerable side effects, highlighting an urgent need therapeutic strategies. This study investigates pathological conditions ischemia hypoxia in SCI region, complemented by early transcriptome sequencing postinjury. Our findings suggest that targeting ferroptosis pivotal neuroprotection following SCI. Aiming at cascade effect mitochondrial damage leading to reactive oxygen species (ROS) production, along with extensive ROS-mediated lysosomal during signaling, we developed liposome-based system regulating iron metabolism─DTLS@CAT. innovative liposome designed specifically target neuronal mitochondria, effectively eliminate mitoROS, modulate complex interactions among metabolism, lysosomes, ROS facilitate recovery from

Language: Английский

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Comparative tissue distribution analysis of Achyranthes bidentata Blume saponins via intragastric, intraperitoneal, and intravenous administration using simultaneous UPLC-MS/MS detection

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100549 - 100549

Published: April 1, 2025

Language: Английский

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Role of sirtuins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic potential

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143591 - 143591

Published: April 27, 2025

The high incidence and mortality rate of cardiac arrest (CA) establishes it as a critical clinical challenge in emergency medicine globally. Despite continuous advances advanced life support (ALS) technology, the prognosis for patients experiencing remains poor, with cerebral ischemia reperfusion injury (CIRI) being significant determinant adverse neurological outcomes increased mortality. Sirtuins (SIRTs) are class highly evolutionarily conserved NAD+-dependent histone deacylenzymes capable regulating expression various cytoprotective genes to play neuroprotective role CIRI. SIRTs mainly regulate levels downstream proteins such PGC 1-α, Nrf 2, NLRP 3, FoxOs, PINK 1 inhibit inflammatory response, attenuate oxidative stress, improve mitochondrial dysfunction, promote angiogenesis, apoptosis while reducing Natural active ingredients widely used protein level body because their multi-components, multi-pathway, multi-target, minimal toxic side effects. However, these naturally still face many challenges related drug targeting, pharmacokinetic properties, delivery. emergence vigorous development new delivery systems, nanoparticles, micromilk, exosomes, provide strong solving above problems. In context rapid molecular biology non-coding RNA (NcRNA), represented by miRNA LncRNA, offers great potential achieving gene-level precision medicine. multidisciplinary integration, combining biotechnology, omics technologies, artificial intelligence, material science will strongly deepening basic research expand application. This review describes major signaling pathways targeting mitigate CIRI, well current status Chinese Western medical means intervention SIRTs. Meanwhile, possible solutions application targeted drugs summarized. industrial crossover, direction future is discussed valuable reference researchers clinicians diagnosis treatment effects

Language: Английский

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Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

Language: Английский

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Exploring the correlation between innate immune activation of inflammasome and regulation of pyroptosis after intracerebral hemorrhage: From mechanism to treatment

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117382 - 117382

Published: Sept. 6, 2024

Language: Английский

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Comprehensive evaluation of EGFR and AKT targeting efficacy of resveratrol loaded PEGylated liposomes for the glioblastoma management: In silico, in vitro BBB permeation studies

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108077 - 108077

Published: Dec. 20, 2024

Language: Английский

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