Colloids and Surfaces B Biointerfaces,
Journal Year:
2024,
Volume and Issue:
245, P. 114189 - 114189
Published: Aug. 29, 2024
With
the
increasing
aging
population,
demand
for
orthopedic
implants
is
also
growing.
Polyether
ether
ketone
(PEEK)
considered
a
promising
material
due
to
its
excellent
biocompatibility.
However,
lack
of
bioactivity
and
excessive
immune
response
post-implantation
often
impair
bone
integration.
Therefore,
it
urgent
bio-functionalize
PEEK-based
promote
This
study
employs
simple,
economical,
feasible
method
coat
Ga-ion
doped
bioactive
glass
nanoparticles
(Ga-MBGs)
onto
sulfonated
PEEK
surfaces,
constructing
multifunctional
implant.
The
resulting
bio-functionalized
macrophage
M2
phenotype
polarization,
thus
fostering
an
anti-inflammatory
microenvironment.
Moreover,
direct
osteogenic
effect
Ga
ions
immuno-osteogenic
through
promoting
polarization
enhance
differentiation
potential
in
vitro
integration
vivo.
A
sequence
vivo
experiments
substantiates
essential
intricate
function
this
innovative
implants.
regulating
normal
immunity
metabolism.
Overall,
application
Ga-MBGs
provides
effective
developing
surface
implant,
capable
modulating
metabolism,
holds
significant
clinical
as
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
distinguished
by
inflammatory
synovitis.
Chrysin
can
alleviate
the
response
and
inhibit
progression
of
RA.
However,
unfavorable
physicochemical
properties
nonselective
biodistribution
chrysin
make
it
difficult
to
achieve
good
therapeutic
efficacy.
To
address
these
challenges,
we
developed
biomimetic
nanocarrier
enhance
targeted
delivery
synoviocytes,
key
cellular
component
in
RA
pathology.
Our
nanodrug,
FMPlipo@C,
was
engineered
integrating
fibroblast-like
synoviocyte
(FLS)
membrane
proteins
into
chrysin-loaded
liposomes.
This
innovative
approach
harnesses
homologous
targeting
mediated
FLS
direct
liposomes
inflamed
joints,
facilitating
cargo
release
within
synoviocytes.
We
showed
that
FMPlipo@C
reduces
inflammation
collagen-induced
rheumatoid
(CIA)
model
mice
inhibiting
HIF-1α/iNOS/NLRP3
pathway,
protecting
cartilage,
preventing
bone
erosion,
thus
reducing
swelling
stiffness.
study
offers
valuable
insights
development
novel
strategies
for
treatment
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 26, 2025
Activation
of
cGAS-STING
signaling
pathway
and
accumulation
reactive
oxygen
nitrogen
species
(RONS)
are
important
issues
facing
the
treatment
rheumatoid
arthritis
(RA).
Here,
we
report
a
biomimetic
nano-Chinese
medicine
(HA-RM-Cel-BR)
for
RA
immunotherapy
based
on
STING
inhibition
celastrol
(Cel)
RONS
clearance
bilirubin
(BR).
HA-RM-Cel-BR
is
constructed
by
carrier-free
self-assembly
active
ingredients
Cel
BR
from
traditional
Chinese
medicine,
then
camouflaged
hyaluronic
acid
(HA)-modified
red
blood
cell
membranes
(RM).
prolongs
circulation
time
through
RM
camouflage,
targets
inflamed
joints
HA
modification,
remodels
joint
immune
microenvironment
clearance.
More
importantly,
shows
excellent
therapeutic
effects
rat
model,
significantly
reduces
hepatotoxicity
associated
with
Cel.
Our
work
provides
new
strategy
ingredients.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 14, 2025
Abstract
The
poor
prognosis
of
rheumatoid
arthritis
(RA)
and
its
potential
for
complications
highlight
the
importance
understanding
factors
that
are
associated
with
incidence
mortality
rates.
inclusion
criteria
this
study
were
RA-related
data
from
1999
to
2018
in
National
Health
Nutrition
Examination
Survey
(NHANES)
dataset.
Based
on
certain
screening
criteria,
a
total
610
subjects
recruited.
Low
CRP
group
(<
3
mg/L)
High
(>
significantly
different
gender,
poverty-to-income
ratio,
body
mass
index,
hypertension,
hemoglobin
(Hb),
hematocrit,
mean
corpuscular
hemoglobin.
KM
survival
result
revealed
male
RA
patients
Hb
had
lower
rate
than
those
(
P
<
0.0001),
while
female
showed
no
statistically
significant
difference
compared
=
0.13).
Importantly,
there
was
nonlinear
relationship
between
all-cause
patients.
In
study,
we
identified
as
protective
factor
against
also
observed
association
RA.
Consequently,
regulating
levels
might
be
considered
progression
