Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Polydatin and chitosan-silver co-loaded nanocomplexes for synergistic treatment of rheumatoid arthritis via repolarizing macrophages and inducing apoptosis of fibroblast-like synoviocytes DOI Creative Commons

Zhaoli Su,

Yuanyuan Tang,

Gejing Li

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 245, P. 113287 - 113287

Published: Aug. 30, 2024

Language: Английский

Citations

1
Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Citations

0