Polydopamine Decorated Hyaluronic Acid Clusters for Tumor Cell Targeting Combination Therapy via Template Self‐Consumption Methods DOI
Hongrui Zhu,

Daqing Xia,

Huan He

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Photothermal‐chemodynamic‐chemotherapy (PTT‐CDT‐CT) combination therapy significantly enhances the therapeutic efficacy against tumors. However, synthesizing PTT‐CDT‐CT nanosystems is complex, typically requiring preparation and conjugation of three components into a single carrier. To overcome this challenge, facile template self‐consumption method developed. In approach, hyaluronic acid (HA), recognized for its tumor cell targeting properties, chelates with Cu 2+ to form Cu‐HA, which then transforms CuO 2 @HA cluster templates. These templates self‐consume gradually, producing ·OH , catalyze rapid polymerization dopamine coordinate polydopamine respectively, enhancing photothermal conversion efficiency. After gossypol loading, GPDA@HA clusters are formed, achieving high loading efficiency due π–π stacking between PDA, as well coordination . The effectively internalized by cells through endocytosis, mediating synergistic damage or inhibition intracellular proteins, nucleic acids via PTT, CDT, CT. Crucially, synergism far surpasses those modality. This work introduces new pathway synthesis nanosystems, avoiding conventional different agents, provides insights developing personalized drug therapies efficacy.

Language: Английский

Metal coordination polymer nanoparticles for cancer therapy DOI Creative Commons
Zhengzheng Zhang, Isra Rana, Jutaek Nam

et al.

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: April 10, 2025

Metal ions are essential elements in biological processes and immune homeostasis. They can regulate cancer cell death through multiple distinct molecular pathways stimulate cells implicated antitumor responses, suggesting opportunities to design novel metal ion-based therapies. However, their small size high charge density result poor target uptake, uncontrolled biodistribution, rapid clearance from the body, reducing therapeutic efficacy increasing potential off-target toxicity. coordination polymer nanoparticles (MCP NPs) nanoscale networks composed of organic ligands linked via noncovalent interactions. MCP NPs offer a promising nanoplatform for reshaping into more drug-like formulations, improving vivo pharmacological performance index therapy applications. This review provides comprehensive overview inherent functions therapy, showcasing examples NP systems designed preclinical applications where drug delivery principles play critical role enhancing outcomes. versatile ion engineering approaches using selected ions, various ligands, functional payloads, enabling on-demand nano-drug designs that significantly improve reduce side effects effective therapy.

Language: Английский

Citations

0
Supramolecular approaches for the treatment of hypoxic regions in tumours DOI
Irene Regeni, Sylvestre Bonnet

Nature Reviews Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Tumor Cell Membrane-Encapsulated Nanoparticles Composed of FeS2 and Radical-Initiator Nanoparticles for Osteosarcoma Cell Death DOI
Jiewen Zheng, Zhen Zuo, Tao Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors DOI

ZhouXue Wu,

Junru Chen,

Biqiong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081

Published: Nov. 1, 2024

Language: Английский

Citations

2
Novel Progress of Covalent Organic Frameworks in the Biomedicine Approaches: From Synthesis to Cutting Edge Therapeutics DOI
Mojtaba Moharramnejad, Taraneh Sayah,

Zahra Ghehsareh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106320 - 106320

Published: Oct. 23, 2024

Language: Английский

Citations

1
Polydopamine Decorated Hyaluronic Acid Clusters for Tumor Cell Targeting Combination Therapy via Template Self‐Consumption Methods DOI
Hongrui Zhu,

Daqing Xia,

Huan He

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Photothermal‐chemodynamic‐chemotherapy (PTT‐CDT‐CT) combination therapy significantly enhances the therapeutic efficacy against tumors. However, synthesizing PTT‐CDT‐CT nanosystems is complex, typically requiring preparation and conjugation of three components into a single carrier. To overcome this challenge, facile template self‐consumption method developed. In approach, hyaluronic acid (HA), recognized for its tumor cell targeting properties, chelates with Cu 2+ to form Cu‐HA, which then transforms CuO 2 @HA cluster templates. These templates self‐consume gradually, producing ·OH , catalyze rapid polymerization dopamine coordinate polydopamine respectively, enhancing photothermal conversion efficiency. After gossypol loading, GPDA@HA clusters are formed, achieving high loading efficiency due π–π stacking between PDA, as well coordination . The effectively internalized by cells through endocytosis, mediating synergistic damage or inhibition intracellular proteins, nucleic acids via PTT, CDT, CT. Crucially, synergism far surpasses those modality. This work introduces new pathway synthesis nanosystems, avoiding conventional different agents, provides insights developing personalized drug therapies efficacy.

Language: Английский

Citations

0