Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications DOI Creative Commons
Zhaoyang Wang, Hạixia Chen,

Jing Yang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114026 - 114026

Published: May 1, 2025

Language: Английский

Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections DOI

Quanyi Lu,

Xiangsheng Tang,

Bailong Tao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139685 - 139685

Published: Jan. 10, 2025

Language: Английский

Citations

3
Engineered hydrogel platform for diabetic wound healing DOI
Jie Cui, Jianbin Shi, Yanjun Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

Citations

1
An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration DOI Creative Commons
Q. J. Guo,

Ruojing Li,

Yeying Zhao

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 10, 2025

Bacterial infection, a complex wound microenvironment, and persistent inflammatory response in acute wounds can result delayed healing abnormal scar formation, thereby compromising the normal function aesthetic appearance of skin tissue. This issue represents one most challenging problems clinical practice. study aims to develop hydrogel dressing specifically designed for treatment wounds, providing immediate effective protection affected areas. innovation seeks offer novel advanced solution management wounds. In this study, composite scaffold was synthesized through reaction between oxidized glycyrrhizic acid carboxymethyl chitosan Schiff base. The material properties were systematically characterized, its biocompatibility antibacterial efficacy rigorously evaluated. A rat model established compare multiple groups, assessing impact on microenvironment repair. results demonstrated that OGA-CMCS exhibited excellent injectability, biocompatibility, properties. It capable enhancing which turn influenced polarization macrophages from M1 M2 phenotype, mitigating response, promoting angiogenesis granulation tissue regeneration, accelerating healing. successfully developed glycyrrhizin-based dressing, not only introduces innovative approaches emergency surface defects but also provides an experimental foundation. is anticipated contribute significantly addressing relevant challenges.

Language: Английский

Citations

0
Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management DOI
Zhibin Wu, Dongdong Lu, Shuo Sun

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.

Language: Английский

Citations

0
Improved antibacterial activity of a sustained-release biocompatible nanofilm for treating Pseudomonas aeruginosa wound infection in vitro and in vivo DOI Creative Commons

Feifei Lu,

Guoxiu Lu, Zhiguo Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial anti-inflammatory activities promotes wound healing. developed on the basis successful preparation its nanoemulsion PVA-CS film then important properties system, including morphological physicochemical characteristics, stability safety, antimicrobial efficacy against P. aeruginosa also evaluated in vitro vivo. effect, healing effect inflammatory factor change vivo were evaluated. These results revealed good particle size (59.27 nm) stable zeta potential (-15.2 mV) are suitable applications. Additionally, it stable, exhibited long-term (24 months) sustained release simulated fluid. Results showed does not induce dose-related toxic effects displays better occurs more quickly, two times greater than CHX vitro. This safe enhances activity 14 days, modulates immune response, accelerates skin insights into multifunctional designs improved suggest promising clinical

Language: Английский

Citations

0
Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications DOI Creative Commons
Zhaoyang Wang, Hạixia Chen,

Jing Yang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114026 - 114026

Published: May 1, 2025

Language: Английский

Citations

0