Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 13, 2025
Fatty
acids
disorders
may
lead
to
insulin
resistance,
resulting
in
long-term
oxidative
stress
and
inflammatory
processes,
both
mediated
by
adipose
tissue.
Either
normal
condition
or
obesogenic
status,
cells
components
play
an
important
role
several
physiological
metabolic
conditions.
It
has
been
shown
that
bioactive
compounds
can
influence
the
development
of
obesity
its
pathological
complications
such
as
resistance.
In
this
study,
we
performed
a
network
between
tissue
vis-a-vis
We
constructed
regulatory
62
adipocyte
cell
incorporates
current
evidence
cellular
molecular
interactions
involved
healthy
states.
The
incorporated
information
about
inflammation
pathways
inhibition
signaling;
signaling
GLUT
4
translocation;
triglycerides
production;
ATP
M2
macrophages
recruitment;
adipogenesis
lipolysis
well
mitochondrial
biogenesis.
Our
mathematical
model
showed
discernment
impact
various
substances
on
transitions
from
health
vice
versa.
found
anthocyanins,
punicalagin,
oleanolic
acid,
NRG4
proved
be
critical
nodes
transition
state,
due
their
switch-on
potential
up-regulate
complex
beneficial
transition.
Archives of Dermatological Research,
Journal Year:
2025,
Volume and Issue:
317(1)
Published: April 1, 2025
Individuals
with
type
2
diabetes
mellitus
(T2DM)
not
only
face
the
risk
of
difficult
wound
healing
after
trauma
or
surgery
but
also
struggle
scar
formation
healing.
However,
relationship
between
T2DM
and
hypertrophic
scars
(HS)
remains
unclear.
First,
data
sets
related
to
HS
were
downloaded
from
OpenGWAS
database.
Second,
inverse
variance-weighted
(IVW)
technique
was
employed
assess
causal
impact
on
utilizing
mendelian
randomization
(MR).
Finally,
sensitivity
analyses
reverse
MR
performed
determine
robustness
findings
examine
potential
for
causation.
A
positive
observed.
Three
suitable
datasets
analysis
obtained
using
ids
ebi-a-GCST006867,
ebi-a-GCST007515,
ebi-a-GCST007516
(A
total
206,572
cases
753,191
controls
included).
The
(finn-b-L12_HYPETROPHICSCAR)
dataset
comprised
766
207,482
controls.
IVW
model
results
showed
odds
ratio
(OR)
1.213
(95%
confidence
interval
(CI):
1.04-1.41,
p
=
0.0137),
1.300
CI:
1.05-1.61,
0.017),
1.284
1.03-1.60,
0.0276),
respectively.
stable
without
any
significant
bias
causality.
This
study
systematically
explored
first
time,
provided
a
quantitative
effect
assessment.
consistency,
which
indicated
biological
mechanism
clinical
intervention
direction.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 2417 - 2426
Published: Oct. 1, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
(UV)
radiation,
is
characterized
by
intricate
biological
changes
involving
oxidative
damage
and
structural
alterations.
Despite
an
increasing
demand
for
effective
interventions,
the
current
therapeutic
options
treating
skin
photoaging
are
limited.
We
discovered
through
literature
data
search
on
PubMed
that
recent
research
has
shifted
its
focus
application
of
microneedle
patches
as
innovative
approach
address
this
concern.
Microneedle
patches,
serving
a
novel
transdermal
delivery
system,
exhibit
potential
deliver
bioactive
substances
such
cytokines,
cellular
vesicles,
gene
fragments
even
alive
algae
mitigate
effects
photoaging.
This
review
aims
provide
comprehensive
overview
advancements
in
about
utilizing
treatment
future
directions
leveraging
clinical
agents
rejuvenation.
Ultimately,
we
believe
have
broader
prospect
fields
medical
cosmetology
anti-photoaging.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
