Modulating Osteoclast Activity and Immune Responses with Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes for Osteoporotic Bone Regeneration DOI Creative Commons
Zhen Wang, Ping‐Hua Xiang, Zhe Xu

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 162 - 162

Published: May 4, 2025

Introduction: Osteoporosis results from the dysregulation of osteoclast activation mechanisms. The subsequent inflammation in osteoporotic environments further hampers bone healing and impedes osseointegration. Therefore, developing treatments that can modulate activity regulate immune responses is essential for effectively treating defects. Methods: In this study, silver nanoparticle-decorated TiO2 nanotubes (Ag@TiO2-NTs) were synthesized through an electrochemical anodization technique surface modification. morphology elemental composition Ag@TiO2-NTs structures characterized using scanning electron microscopy (SEM) related methods. Subsequently, a series vitro vivo experiments conducted to investigate regenerative potential assays focused on evaluating cell viability function, while assessments employed rat models monitor via histological examination micro-computed tomography (micro-CT) imaging. Results: Our demonstrated Ag@TiO2, controlled release trace amounts ions, significantly suppressed consequently alleviated resorption under conditions. addition, facilitated polarization macrophages toward M2 phenotype. These biological effects associated with stimulation autophagy, fundamental mechanism involved cellular repair. Moreover, autophagy contributed suppression RANKL-induced NF-κB signaling, pathway regulation metabolism Conclusion: suggest modification strategy has be ideal implant biomaterial defects promising future surgeries.

Language: Английский

Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges DOI Creative Commons

Zhanli Yang,

Weiwei Guo, Wenhao Yang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113716 - 113716

Published: Feb. 1, 2025

Language: Английский

Citations

1
Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway DOI Creative Commons
Yizhou Wan, Qing Gao, Bing Ye

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101588 - 101588

Published: Feb. 19, 2025

Language: Английский

Citations

0
Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis DOI Creative Commons
Li Lü,

Jiewen Liao,

Chao Xu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Continuously bacterial infection, undue oxidative stress, and inflammatory responses in the skin tissue microenvironment determine delayed healing outcome of diabetic wounds, which remain a tough clinical challenge need multifaceted therapeutic strategies. In this work, HA‐ADH/HA‐QA‐ALD‐based hydrogel microneedle (HAQA‐MN) with antimicrobial antioxidative activities incorporating kinsenoside (KD) coated macrophage membrane (M‐KD) targeting inflammation relief is developed to improve cutaneous micro‐niche. KD observed trigger trimethylamine N‐oxide‐irritated proinflammatory macrophages repolarization from M1 state anti‐inflammatory M2 phenotype, underlying mechanism due drug‐induced IRE1α/XBP1/HIF‐1α pathway suppression, accompanied by diminution glycolysis enhancement phosphorylation, resulting cascade inhibition signaling enhancement. The hydrazone cross‐linked HAQA‐MN possesses favorable biocompatibility, self‐healing, controlled release M‐KD excellent mechanical properties. Moreover, MN patch remarkedly restrains survival E. coli S. aureus eliminates hydrogen peroxide preserve cellular viability. Notably, M‐KD@HAQA‐MN array effectively ameliorates stress facilitate angiogenesis collagen deposition, thereby accelerating regeneration mice full‐thickness defect model. Collectively, study highlights multifunctional platform as promising candidate application for treatment wounds.

Language: Английский

Citations

0
Modulating Osteoclast Activity and Immune Responses with Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes for Osteoporotic Bone Regeneration DOI Creative Commons
Zhen Wang, Ping‐Hua Xiang, Zhe Xu

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 162 - 162

Published: May 4, 2025

Introduction: Osteoporosis results from the dysregulation of osteoclast activation mechanisms. The subsequent inflammation in osteoporotic environments further hampers bone healing and impedes osseointegration. Therefore, developing treatments that can modulate activity regulate immune responses is essential for effectively treating defects. Methods: In this study, silver nanoparticle-decorated TiO2 nanotubes (Ag@TiO2-NTs) were synthesized through an electrochemical anodization technique surface modification. morphology elemental composition Ag@TiO2-NTs structures characterized using scanning electron microscopy (SEM) related methods. Subsequently, a series vitro vivo experiments conducted to investigate regenerative potential assays focused on evaluating cell viability function, while assessments employed rat models monitor via histological examination micro-computed tomography (micro-CT) imaging. Results: Our demonstrated Ag@TiO2, controlled release trace amounts ions, significantly suppressed consequently alleviated resorption under conditions. addition, facilitated polarization macrophages toward M2 phenotype. These biological effects associated with stimulation autophagy, fundamental mechanism involved cellular repair. Moreover, autophagy contributed suppression RANKL-induced NF-κB signaling, pathway regulation metabolism Conclusion: suggest modification strategy has be ideal implant biomaterial defects promising future surgeries.

Language: Английский

Citations

0