Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions DOI

Di Ying,

Tianshou Zhang, Manlin Qi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss destruction of tissue. Traditional transplantation and other clinical approaches often fail to address therapeutic complexities these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential enhance treatment outcomes. This review explores pathogenic mechanisms underlying infected including biofilm formation internalization into cells, which allow bacteria evade host immune system. To control infection facilitate repair, we focus on antibacterial materials regeneration. A detailed introduction is given intrinsically (e.g., metal alloys, oxide materials, carbon-based hydroxyapatite, chitosan, Sericin). The functionality repair can be enhanced through strategies such as incorporation antimicrobial ions, surface modification, combined use multiple treat defects. Key innovations discussed include that release agents, functional contact biomaterials, bioresponsive collectively efficacy. Research translation has also facilitated practical application prevention healing. conclusion, advancements provide promising pathways developing more biocompatible, effective, personalized therapies reconstruct

Language: Английский

Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions DOI

Di Ying,

Tianshou Zhang, Manlin Qi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss destruction of tissue. Traditional transplantation and other clinical approaches often fail to address therapeutic complexities these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential enhance treatment outcomes. This review explores pathogenic mechanisms underlying infected including biofilm formation internalization into cells, which allow bacteria evade host immune system. To control infection facilitate repair, we focus on antibacterial materials regeneration. A detailed introduction is given intrinsically (e.g., metal alloys, oxide materials, carbon-based hydroxyapatite, chitosan, Sericin). The functionality repair can be enhanced through strategies such as incorporation antimicrobial ions, surface modification, combined use multiple treat defects. Key innovations discussed include that release agents, functional contact biomaterials, bioresponsive collectively efficacy. Research translation has also facilitated practical application prevention healing. conclusion, advancements provide promising pathways developing more biocompatible, effective, personalized therapies reconstruct

Language: Английский

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