Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

As two main phototherapy means, photodynamic therapy (PDT) and photothermal (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), thus PDT or PTT efficiency can be regulated regulating PSs aggregation. A co‐assembly formulation consisting IR780 iodide pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed coating with hyaluronic acid. Initially, uniform distribution favors more reactive oxygen species birth to implement when entering cells since its avenue sequential process intersystem crossing transfer–collision energy transfer predominant. After hyaluronidase laser irradiation‐induced structural collapse co‐assembly, free aggregates due hydrophobic interactions even though they are excreted out cells, then, these produce heat nonradiative relaxation execute PTT. Such a spatiotemporal PDT–PTT encourages antitumor immune responses mitigates immunosuppression, accomplishing photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable laser‐duration‐decided alteration, switching insights provided into single PSs‐mediated photoimmunotherapy.

Language: Английский

Nonfouling Core–Shell Microneedle for Sequential and Sustained Drug Release: Enhancing Synergistic Photothermal Chemotherapy in Melanoma Treatment

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Melanoma is a highly aggressive and metastatic malignancy, where current treatment methods often result in damage to healthy tissues, suboptimal therapeutic outcomes, immune-related side effects. Microneedles, as drug delivery system, offer advantages such localized administration, minimal invasiveness, high efficiency. In this study, we first synthesized tetradecyl-thiol-grafted PAMAM dendrimers, which significantly enhanced cellular uptake enabled sustained release of doxorubicin (DOX), improving cumulative Based on this, developed core-shell structured zwitterionic polymer-based microneedle system. The outer shell, loaded with the photothermal agent indocyanine green (ICG), achieved precise therapy under near-infrared irradiation, effectively targeting melanoma tissues. inner core, composed polymer matrix, encapsulated DOX-loaded enabling controlled prolonged through gradual swelling dendrimer expansion. Experiments show that system based grafted tetradecyl mercaptan has excellent anti protein adsorption properties, it can minimize cytotoxicity carrier improve efficiency delivery. This inhibited tumor growth synergistic photothermal-chemotherapy, reducing systemic toxicity bioavailability. platform provides promising strategy for targeted therapy, offering high-efficiency low-toxicity alternative.

Language: Английский