Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance DOI Creative Commons
Wenjun Meng, Li Huang,

Jia‐Min Guo

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1549 - 1549

Published: Dec. 3, 2024

Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve efficacy reduce toxic side effects. This review examines impact TME on recent advances in nanomedicine overcome this challenge. Characteristics such as hypoxia, acidity, high interstitial pressure significantly effectiveness chemotherapy radiotherapy, leading increased cells. Then, summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, multifunctional nanosystems that enable targeted release improved penetration accumulation tumors. combining with therapeutic strategies, offers a novel perspective by focusing design nanocarriers interact TME, dimension often overlooked similar reviews. We highlight dual role modulation, emphasize their resistance, look at future research directions.

Language: Английский

Artificial cells and Biomimicry cells: A Rising Star in the Fight Against Cancer DOI Creative Commons

Renata Faria Maia,

Asma Sadat Vaziri, Mohammad‐Ali Shahbazi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101723 - 101723

Published: April 1, 2025

Biomimetic Artificial Cells (ACs) are engineered systems that mimic the properties and functions of natural cells, offering significant potential for biomedical applications. The performance applicability these synthetic constructs depend on choice materials fabrication methods. Our review delves into materials, techniques, diverse applications ACs, emphasizing their transformative impact field cancer therapy as smart vehicles drug delivery, immune system stimulation, cell targeting to minimize off-target effects maximizing therapeutic efficacy well in vitro models research. By providing a comprehensive overview, we aim elucidate how cells can move forward, innovative solutions longstanding challenges treatment opening new frontiers less toxic options.

Language: Английский

Citations

0
Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy DOI Creative Commons
Jiawei Yang, Xueqi Li, Tongyu Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101726 - 101726

Published: April 1, 2025

Language: Английский

Citations

0
Cell membrane derived biomimetic nanomedicine for precision delivery of traditional Chinese medicine in cancer therapy DOI

Hang Xiao,

Faisal Raza, Kunwei Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113829 - 113829

Published: May 1, 2025

Language: Английский

Citations

0
Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance DOI Creative Commons
Wenjun Meng, Li Huang,

Jia‐Min Guo

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1549 - 1549

Published: Dec. 3, 2024

Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve efficacy reduce toxic side effects. This review examines impact TME on recent advances in nanomedicine overcome this challenge. Characteristics such as hypoxia, acidity, high interstitial pressure significantly effectiveness chemotherapy radiotherapy, leading increased cells. Then, summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, multifunctional nanosystems that enable targeted release improved penetration accumulation tumors. combining with therapeutic strategies, offers a novel perspective by focusing design nanocarriers interact TME, dimension often overlooked similar reviews. We highlight dual role modulation, emphasize their resistance, look at future research directions.

Language: Английский

Citations

3