Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

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Multifunctional Waterproof Hydrogels Based on Copper Sulfide Nanoparticles for Burn Wound Healing

Journal of Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Burn wounds care and healing are very difficult in clinic. Herein, a multifunctional waterproof hydrogel was fabricated with photothermal antimicrobial NO anti‐inflammatory properties. In the as‐prepared hydrogel, polyethyleneimine (PEI) thioctic acid (TA) were cross‐linked by electrostatic interactions hydrogen bonding while aggregation of TA could be favor to formation hydrophobic caves. Benefit from caves, CuS BNN6 (N, N′‐dibutyl‐N, N′‐dinitroso‐1,4‐phenylenediamine) incorporated PEI/TA‐based air permeability also increased. Interestingly, mild increased temperature conversion not only endowed ability but promoted release BNN6. The PEI/TA/CuS/BNN6 good biocompatibility, self‐healing water resistance suitable for promoting burn healing. It provides new platform designing novel wound dressing wounds.

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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Progress in Advanced Composite Hydrogel Dressings: Innovative Materials and Designs for the Treatment of Chronic Wounds

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(8)

Published: Feb. 1, 2025

Abstract Chronic wounds, as a kind of long‐term disease that is difficult to cure, are challenged in healthcare, placing substantial physical, emotional, and economic burdens on patients society. Effective treatment chronic wounds essential for improving patient quality life, reducing healthcare costs, alleviating the strain medical resources. Hydrogel materials have emerged promising candidates wound due their exceptional adaptability environments ability deliver various therapeutic agents, effectively promoting healing wounds. However, wide array available with diverse functionalities presents challenge selecting most appropriate components synthesizing hydrogel dressings. This review summarizes common materials, including properties, cross‐linking methods, applications. Additionally, it systematically categorizes different elucidating action mechanisms effects. Furthermore, this work offers guidance material selection dressing design based characteristics Finally, challenges future perspectives composite hydrogels field dressings discussed. provides readers comprehensive understanding reliable basis synthesize ideal

Language: Английский

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Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, ability mimic the natural extracellular matrix. Their 3D porous structure allows encapsulation delivery of bioactive molecules, making them ideal candidates drug systems. In repair, particularly bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or association (BMP@ZIF@GelMA) into gelatin modified by methacryloyl hydrogel (GelMA) investigate its physical osteogenic properties. characterized Scanning Electron Microscopy rheological tests. We analyzed degradation BSA profile BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, 28 days. Cell adhesion formation markers hydrogel-encapsulated dental pulp cells using immunocytochemistry molecular analysis. ZIF@GelMA exhibited viscoelastic increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed balanced rate BSA. The upregulated expression cell genes, BMP-2 introduced, levels remarkably elevated. presents several favorable factors promote cellular encouraging further prospects advanced applications repair.

Language: Английский

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Self-healing hydrogel based on polyvinyl alcohol/dextran with hyperglycemia-triggered cascade enzyme catalytic activity promotes diabetic wound healing

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137615 - 137615

Published: April 16, 2025

Language: Английский

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