Cited by Hyaluronic acid regulated facile synthesis of size-tunable multifunctional nanomedicine for effective cancer therapy

Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy DOI

Guangjian Hou, Yukun Xu, Chunhua Wang

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Language: Английский

Citations

Focusing on ferroptosis in alveolar bone loss during periodontitis: From mechanisms to therapies DOI

Y J Tang, Jianhang Leng, Yankun Luo

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114683 - 114683

Published: April 18, 2025

Language: Английский

Citations

Advancing Cancer Therapy with Nanomaterials Targeting Metalloptosis Mechanisms DOI

Girish Sharma,

Anita Mittal,

Tarun Kumar Batra

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 503 - 530

Published: April 25, 2025

Despite the widespread use of traditional cancer therapies such as surgery, chemotherapy, and radiation, these approaches often suffer from significant drawbacks. Nanomaterials (NMs) are a promising alternative due to their distinct nanoscale properties which enable more precise drug delivery reduced off-target effects. Recently, cuproptosis ferroptosis have emerged novel forms programmed cell death regulated by metal ions, offering pathways for therapy. Cuproptosis, caused copper ion accumulation, leads mitochondrial dysfunction, while ferroptosis, driven iron-mediated lipid peroxidation, disrupts cellular integrity through oxidative stress. Here, we propose explore how NMs can be harnessed induce metalloptosis, advanced treatment strategies. Variations in NM size, morphology, synergistic effects composite complicate identification individual mechanisms. Use therapy, requires focusing on design regulation metalloptosis pathways.

Language: Английский

Citations

Hyaluronic acid regulated facile synthesis of size-tunable multifunctional nanomedicine for effective cancer therapy DOI

Xiuliang Dai,

Yina Yin,

Cheng Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138668 - 138668

Published: Dec. 11, 2024

Language: Английский

Citations