ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(15)
Published: April 1, 2025
Abstract
This
study
introduces
innovative
redox‐sensitive
polymeric
nanocarriers
designed
to
deliver
the
photosensitizer
meso
‐tetra(
N
‐methyl‐4‐pyridyl)porphine
and
enhance
anticancer
photodynamic
therapy.
These
release
from
a
hydrophobic
core
in
response
elevated
glutathione
levels,
enabling
generation
of
reactive
oxygen
species
upon
irradiation.
The
glutathione‐sensitive
is
constructed
using
disulfide‐linked
molecules,
while
hydrophilic
shell,
consisting
6‐methyluracil
derivative,
enhances
stability
promotes
cellular
uptake
photosensitizer.
paper
details
synthesis,
physicochemical
properties,
encapsulation
efficiency
nanocarriers.
It
further
explores
how
structure
influences
glutathione‐induced
degradation,
kinetics,
under
Additionally,
evaluates
hemocompatibility
photosensitizer/nanocarrier
composites
their
cytotoxic
effects
on
human
liver
cells
(Chang
Liver),
healthy
embryonic
lung
(WI38),
cancer
cell
lines
(M‐HeLa
HuTu80).
Notably,
treatment
with
these
composites,
followed
by
irradiation,
significantly
reduces
viability
M‐HeLa
line,
demonstrating
potential
for
targeted
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 245 - 245
Published: Feb. 13, 2025
Recent
advancements
in
nanotechnology
have
revolutionized
cancer
therapy-one
of
the
most
pressing
global
health
challenges
and
a
leading
cause
death-through
development
liposomes
(L),
lipid-based
nanovesicles
known
for
their
biocompatibility
ability
to
encapsulate
both
hydrophilic
lipophilic
drugs.
More
recent
innovations
led
creation
stimuli-responsive
L
that
release
payloads
response
specific
endogenous
or
exogenous
triggers.
Dual-
multi-responsive
L,
which
react
multiple
stimuli,
offer
even
greater
precision,
improving
therapeutic
outcomes
while
reducing
systemic
toxicity.
Additionally,
these
smart
can
adjust
physicochemical
properties
morphology
enable
site-specific
targeting
controlled
drug
release,
enhancing
treatment
efficacy
minimizing
adverse
effects.
This
review
explores
latest
liposomal
nanocarriers,
as
well
dual-
integrate
internal
external
triggers,
with
focus
on
design
strategies,
mechanisms,
applications
therapy.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(3)
Published: Feb. 23, 2025
Ferroptosis
is
a
distinct
form
of
iron-dependent
programmed
cell
death
characterized
primarily
by
intracellular
iron
accumulation
and
lipid
peroxidation.
Multiple
cellular
processes,
including
amino
acid
metabolism,
various
signaling
pathways,
autophagy,
have
been
demonstrated
to
influence
the
induction
progression
ferroptosis.
Recent
investigations
elucidated
that
ferroptosis
plays
crucial
role
in
pathogenesis
pulmonary
disorders,
lung
injury,
chronic
obstructive
disease,
fibrosis,
asthma.
increasingly
recognized
as
promising
novel
strategy
for
cancer
treatment.
Various
immune
cells
within
tumor
microenvironment,
CD8+
T
cells,
macrophages,
regulatory
natural
killer
dendritic
shown
induce
modulate
process
through
regulation
metabolism
pathways.
Conversely,
can
reciprocally
alter
metabolic
environment,
leading
activation
or
inhibition
functions,
thereby
modulating
responses.
This
paper
reviews
molecular
mechanism
describes
discusses
connection
between
microenvironment
diseases,
development
prospect
their
interaction
treatment
diseases.
Applied Biosciences,
Journal Year:
2025,
Volume and Issue:
4(1), P. 16 - 16
Published: March 5, 2025
Hematologic
malignancies,
including
leukemia,
lymphoma,
and
multiple
myeloma,
pose
significant
therapeutic
challenges
due
to
their
heterogeneity
high
relapse
rates.
Nanotechnology
has
emerged
as
a
promising
avenue
for
precision
drug
delivery
in
these
allowing
enhanced
concentration
at
tumor
sites
reducing
systemic
toxicity.
Recent
developments
nanocarriers—such
liposomes,
polymeric
nanoparticles,
inorganic
nanoparticles—have
enabled
targeted
approaches,
utilizing
molecular
markers
specific
malignant
cells
increase
efficacy
while
minimizing
adverse
effects.
Evidence
from
preclinical
clinical
studies
underscores
the
potential
of
nanotechnology
improve
patient
outcomes
by
facilitating
controlled
release,
improved
bioavailability,
reduced
However,
translating
advancements
into
practice
requires
further
research
validate
safety
efficacy.
This
review
provides
comprehensive
analysis
latest
innovations
hematologic
addressing
current
achievements
future
directions
integrating
approaches
Clinical
Hemato-Oncology.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 26, 2025
Abstract
Background
Ferroptosis
is
an
emerging
cell
death
mechanism
characterized
by
uncontrolled
lipid
peroxidation.
However,
selectively
inducing
ferroptosis
in
cancer
cells
remains
a
challenge.
Methods
We
explore
approach
that
enables
induction
through
external
radiation.
The
key
component
of
this
technology
7-dehydrocholesterol
(7DHC),
natural
biosynthetic
precursor
cholesterol.
To
facilitate
delivery,
we
demonstrate
7DHC,
like
cholesterol,
can
be
incorporated
into
the
layer
liposomes.
enhance
targeting,
also
introduced
NTS
mut
,
ligand
for
neurotensin
receptor
1
(NTSR1),
which
overexpressed
multiple
malignancies,
Results
Under
radiation,
7DHC
reacts
with
radiation-induced
reactive
oxygen
species
(ROS),
initiating
radical
chain
reaction
polyunsaturated
fatty
acids
(PUFAs)
membranes.
This
process
results
direct
peroxidation
and
subsequent
ferroptotic
death.
In
vivo
studies
-conjugated,
7DHC-loaded
liposomes
(N-7DHC-lipos)
effectively
accumulate
tumors
significantly
efficacy
radiation
therapy.
Conclusion
While
conventional
radiosensitizers
primarily
target
DNA
its
repair
mechanisms,
our
study
introduces
strategy
to
radiotherapy
specifically
activating
within
irradiated
area,
thereby
minimizing
systemic
toxicity.
Such
controlled
activation
offers
favorable
therapeutic
index
potentially
opens
avenues
clinical
application.
