Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications DOI Creative Commons
Yunxi Chen,

Noélie Douanne,

T.-C. Wu

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(9)

Published: Feb. 26, 2025

Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.

Language: Английский

Citations

2
Recent Advances in Indocyanine Green-Based Probes for NIR-II Fluorescence Imaging and Therapy DOI Creative Commons
Dehong Hu,

Menglei Zha,

Hairong Zheng

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution compared traditional (NIR) imaging. Indocyanine green (ICG), US Food Drug Administration-approved NIR fluorophore, long been used in applications, including blood vessel angiography, vascular perfusion monitoring, tumor detection. Recent advancements NIR-II technology have revitalized interest ICG, revealing extended tail fluorescence beyond nm reaffirming potential clinically translatable fluorophore for vivo theranostic applications diagnosing various diseases. This review emphasizes notable advances use ICG derivatives image-guided therapy from both fundamental perspectives. We provide concise conclusion discuss challenges future opportunities with using approved fluorophores.

Language: Английский

Citations

4
Dual-Modal Super-Resolution Ultrasound and NIR-II Fluorescence Imaging of Ischemic Stroke with ICG-doped Porous PLGA Microspheres DOI Creative Commons
Ziyue Li, Qiang Yu,

Dongli Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101513 - 101513

Published: Jan. 22, 2025

Language: Английский

Citations

0
Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis DOI

Mo Chen,

Zhenhua Wang,

Haolong Chen

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease distinguished by inflammatory synovitis. Chrysin can alleviate the response and inhibit progression of RA. However, unfavorable physicochemical properties nonselective biodistribution chrysin make it difficult to achieve good therapeutic efficacy. To address these challenges, we developed biomimetic nanocarrier enhance targeted delivery synoviocytes, key cellular component in RA pathology. Our nanodrug, FMPlipo@C, was engineered integrating fibroblast-like synoviocyte (FLS) membrane proteins into chrysin-loaded liposomes. This innovative approach harnesses homologous targeting mediated FLS direct liposomes inflamed joints, facilitating cargo release within synoviocytes. We showed that FMPlipo@C reduces inflammation collagen-induced rheumatoid (CIA) model mice inhibiting HIF-1α/iNOS/NLRP3 pathway, protecting cartilage, preventing bone erosion, thus reducing swelling stiffness. study offers valuable insights development novel strategies for treatment

Language: Английский

Citations

0
Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma DOI Creative Commons

Kaifen Xiong,

Guanghong Luo,

Wei Zeng

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2901 - 2921

Published: March 1, 2025

Background: Melanoma poses a significant threat to human health due the lack of effective treatment options. Previous studies have demonstrated that combination photothermal therapy (PTT) and photodynamic (PDT) can enhance therapeutic efficacy. However, conventional PTT/PDT strategies face various challenges, including complex preparation processes, potential damage healthy tissues, insufficient generation reactive oxygen species (ROS). This study aims design rational efficient strategy for melanoma explore its underlying mechanisms. Methods: We first synthesized two target materials, indocyanine green-targeted liposomes (ICG-Lips) magnetic microbubbles (MMBs), using thin-film hydration method, followed by characterization performance evaluation both materials. Subsequently, we evaluated synergistic effects mechanisms ICG-Lips combined with MMBs in through vitro experiments cellular models vivo animal models. Results: Herein, developed multifunctional system comprising MMBs. targeted delivery specific binding S100B protein on cells, while MMBs, via ultrasound (US)-induced cavitation effects, shorten uptake time cells improve efficiency. Furthermore, induces (ROS) generation. Under 808 nm laser irradiation, accumulation achieves mild (mPTT) PDT effects. The elevated temperature excessive ROS generated during these processes result glutathione (GSH) depletion, ultimately triggering ferroptosis. occurrence ferroptosis further amplifies efficacy, creating effect effectively suppresses growth. Additionally, demonstrates excellent biosafety. Conclusion: In summary, this presents novel straightforward integrates mPTT, PDT, synergistically combat melanoma, thereby laying solid foundation improving outcomes. Keywords: microbubbles, ferroptosis, mild-temperature therapy,

Language: Английский

Citations

0
Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors DOI Creative Commons
Zhiguang Chen, Liang Sang,

Zhai Qixi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661

Published: March 1, 2025

Language: Английский

Citations

0
State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches DOI Creative Commons
Bruno Agustín Cesca,

K. Martin,

Matías Daniel Caverzán

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature resistance conventional therapies, including surgery, chemotherapy, radiotherapy. Despite advances in standard treatments, patient survival remains limited, requiring exploration of innovative strategies. Photodynamic therapy (PDT) has emerged as promising approach, leveraging light-sensitive photosensitizers (PSs), molecular oxygen, specific light wavelengths generate reactive oxygen species (ROS) that selectively induce tumor cell death. Originally developed for skin cancer, PDT evolved target more complex malignancies, GBM. The refinement second- third-generation PS, coupled with advancements nanotechnology, significantly improved PDT's selectivity, bioavailability, efficacy. Moreover, combination targeted therapy, immunotherapy, among other modalities, shown potential enhancing outcomes. This review provides comprehensive analysis preclinical clinical applications GBM, detailing mechanisms action, evolution novel combinatory strategies optimize treatment However, several challenges remain, overcoming GBM-associated hypoxia, PS delivery across blood-brain barrier, mitigating mechanisms. integration genetic insight, alongside cutting-edge nanotechnology-based systems, may revolutionize GBM treatment, offering new prospects quality life.

Language: Английский

Citations

0
Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Citations

0