Hydrophobic group modification for constructing self-assembling antimicrobial peptide derivatives with superior antimicrobial performance

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162645 - 162645

Published: April 1, 2025

Language: Английский

Self‐Assembled Poly(sarcosine) Functionalized Host Defense Peptide‐Mimicking Poly‐β‐Peptides for Combating Drug‐Resistant Fungal Infection

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The scarcity of clinically available antifungal drugs, coupled with frequent side effects and the accelerating emergence fungal drug resistance, underscores pressing demand for novel drugs. Host defense peptide (HDP) assemblies are one ideal alternatives to drugs due distinctive advantages nanostructures, but still face challenges in terms vivo stability, biosafety, facile synthesis. Poly‐β‐peptides a class polypeptide mimics that possess excellent biocompatibility resistance proteolysis, however, their antimicrobial have yet be explored. Herein, poly‐β‐peptide poly(sarcosine) integrated design self‐assembled functionalized HDP mimics, while establishing one‐pot, open‐vessel synthesis method block‐like poly‐β‐peptide. synthesized multifunctional exhibit potent highly selective activity against drug‐resistant fungi effectively eradicate mature biofilms, demonstrate efficacy. Notably, insusceptible acquire owing mechanisms associated organelle destruction reactive oxygen species. These results potential strategy developing combating infections.

Language: Английский

Abundance of Antimicrobial Peptides in Mesenchymal Stem Cells and Tissues: Variations Among Species

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: May 26, 2025

Language: Английский