Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse at late stage, significantly impairing joint function. While MRI highly effective tool for diagnosing ONFH its early stages, challenges remain due to limited availability high cost MRI, as well absence routine screening asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying drugs are still under investigation/development. Considering that supply plays key role pathology ONFH, angiogenic therapies have been put forward promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold potential treatment. this review, we introduce advances research into summarize novel angiogenesis. review sheds light upon new directions future ONFH.

Language: Английский

The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 70 - 84

Published: April 10, 2025

Language: Английский