Advances in Oral Biomacromolecule Therapies for Metabolic Diseases
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 238 - 238
Published: Feb. 12, 2025
Metabolic
diseases
like
obesity
and
diabetes
are
on
the
rise,
therapies
with
biomacromolecules
(such
as
proteins,
peptides,
antibodies,
oligonucleotides)
play
a
crucial
role
in
their
treatment.
However,
these
drugs
traditionally
injected.
For
patients
chronic
(e.g.,
metabolic
diseases),
long-term
injections
accompanied
by
inconvenience
low
compliance.
Oral
administration
is
preferred,
but
delivery
of
challenging
due
to
gastrointestinal
barriers.
In
this
article,
we
introduce
available
biomacromolecule
for
treatment
diseases.
The
barriers
oral
drug
strategies
overcome
also
explored.
We
then
discuss
alleviating
defects,
including
glucose
metabolism,
lipid
energy
such
insulin,
glucagon-like
peptide-1
receptor
agonists,
proprotein
convertase
subtilisin/kexin
type
9
inhibitors,
fibroblast
growth
factor
21
analogues,
peptide
YY
analogues.
Language: Английский
Immune Modulation with Oral DNA/RNA Nanoparticles
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 609 - 609
Published: May 4, 2025
The
oral
delivery
of
DNA/RNA
nanoparticles
represents
a
transformative
approach
in
immunotherapy
and
vaccine
development.
These
enable
targeted
immune
modulation
by
delivering
genetic
material
to
specific
cells
the
gut-associated
system,
triggering
both
mucosal
systemic
responses.
Unlike
parenteral
administration,
route
offers
unique
immunological
environment
that
supports
tolerance
activation,
depending
on
formulation
design.
This
review
explores
underlying
mechanisms
nanoparticles,
their
design
strategies,
recent
advances
application.
Emphasis
is
placed
strategies
overcome
physiological
barriers
such
as
acidic
pH,
enzymatic
degradation,
mucus
entrapment,
epithelial
tight
junctions.
Special
attention
given
role
lymphoid
tissue
mediating
responses
therapeutic
potential
these
systems
platforms,
food
allergies,
autoimmune
diseases,
chronic
inflammation.
Despite
challenges,
nanoparticle
support
translation
technologies
into
clinical
applications
for
immunomodulation
vaccination.
Language: Английский
Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 30, 2025
Abstract
Oral
administration
has
long
been
considered
the
most
convenient
method
of
drug
delivery,
requiring
minimal
expertise
and
invasiveness.
Unlike
injections,
it
avoids
discomfort,
wound
infections,
complications,
leading
to
higher
patient
compliance.
However,
effectiveness
oral
delivery
is
often
hindered
by
harsh
biological
barriers
gastrointestinal
tract,
which
limit
bioaccessibility
bioavailability
drugs.
The
development
systems
(ODDSs)
represents
a
critical
area
for
advancement
pharmacotherapy.
This
review
highlights
characteristics
precise
targeting
mechanisms
ODDSs.
It
first
examines
unique
properties
each
compartment,
including
stomach,
small
intestine,
intestinal
mucus,
epithelial
barrier,
colon.
Based
on
these
features,
outlines
strategies
design
principles
ODDSs
aimed
at
overcoming
enhance
disease
treatment.
Lastly,
discusses
challenges
potential
future
directions
ODDS
development,
emphasizing
their
importance
advancing
technologies
accelerating
growth.
Graphical
Language: Английский