Neoplasia, Journal Year: 2024, Volume and Issue: 60, P. 101102 - 101102
Published: Dec. 13, 2024
Language: Английский
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)
Published: March 5, 2025
The review article provides a short introduction to exosomes with the focus use as disease markers itself (i.e. their concentration or presence of some specific receptors) source biomarkers such proteins and metabolites. In detail, we are discussing various methods exosome isolation main paper is on affinity capture exosomes, since them can be applied sub-populations produced by organs. comprehensive overview magnetic (bio)affinity detection exosomal cargo using different ligands antibodies, DNA aptamers, peptides, glycan-based recognition, transferrin-based approaches, based recognition phospholipids other approaches including electrostatic interactions. in detail key analytical clinical parameters form an extensive table summarising outcomes published last two years (2023-2024). Finally, also conclusions sections pros cons for and/or determination content.
Language: Английский
Citations
1
Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 628 - 628
Published: March 5, 2025
Cancer cells exhibit abnormal behavior compared to normal cells. They ignore growth arrest signals such as contact inhibition, a mechanism that stops their proliferation when they collide with surrounding cells, and proliferate in an uncontrolled manner, destroying tissue. Early detection treatment of cancer are therefore important for healthy longevity. differ from characteristic gene expression due abnormalities. markers reflect these characteristics have been searched applied diagnosis. Although analysis blood antigens has the main method, further development diagnostic system is needed early cancer. Next-generation sequencers improved technology, making it possible analyze detailed nucleic acid molecules or urine. In addition, release extracellular vesicles, exosomes, which known contain may serve markers. This review summarizes latest findings on exosomal
Language: Английский
Citations
0
Extracellular Vesicle, Journal Year: 2025, Volume and Issue: 5, P. 100071 - 100071
Published: March 22, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: May 6, 2025
Bladder cancer, predominantly urothelial carcinoma, is a global health issue with increasing incidences and mortality. It poses significant diagnostic therapeutic challenges due to its molecular heterogeneity the limitations of current detection methods. Extracellular vesicles (EVs), including exosomes, play crucial role in intercellular communication have emerged as potential biomarkers agents bladder cancer. This review focuses on multifaceted roles EVs cancer biology, their biomarkers, use strategies. We discuss how reflect subtypes participate metabolic reprogramming angiogenesis, modulate cellular behavior. The also highlights advances proteomic analysis urinary tissue-exudative EVs, identifying specific proteins RNAs that could serve non-invasive markers. Furthermore, we explore innovative natural nanocarriers for drug delivery treatment, demonstrating enhance efficacy chemotherapy selectively target cells. integration EV-based diagnostics traditional methods lead more personalized effective management, emphasizing need further research clinical validation.
Language: Английский
Citations
0
Neoplasia, Journal Year: 2024, Volume and Issue: 60, P. 101102 - 101102
Published: Dec. 13, 2024
Language: Английский
Citations
0