Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis DOI
Hongqian Liu,

Qiannan Cao,

Yufei Yao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Gene therapy has brought hope for curing major diseases including cancer. However, an efficient and safe delivery system is key successful gene therapy. In this study, PPERD (i.e., OHC‐PEG‐CHO/PEtOx 0.2 ‐PEI 0.73 ‐PRGD 0.07 /DNA), polyoxazoline‐based developed to mediate tumor vascular normalization extracellular matrix (ECM) degradation cancer The aldehyde groups of OHC‐PEG‐CHO can form Schiff base bonds with the amine PER PEtOx ), thereby enabling in situ encapsulation PERD PER/DNA) rapid pH responsiveness tissues. possesses excellent vitro transfection performance good biocompatibility. efficiently accumulate, penetrate, transfect tumors once intravenous administration. effectively normalizes vasculature degradates ECM, enhances infiltration function cytotoxic T lymphocytes, inducing antitumor immune response vivo. Moreover, PPERVH ((i.e., /(pshVEGF+pHAase)) also inhibit recurrence metastasis by triggering durable anti‐tumor memory effect. Furthermore, significantly effectiveness checkpoint blockade‐mediated immunotherapy. This strategy provides a promising paradigm inhibiting growth, recurrence, metastasis.

Language: Английский

Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis DOI
Hongqian Liu,

Qiannan Cao,

Yufei Yao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Gene therapy has brought hope for curing major diseases including cancer. However, an efficient and safe delivery system is key successful gene therapy. In this study, PPERD (i.e., OHC‐PEG‐CHO/PEtOx 0.2 ‐PEI 0.73 ‐PRGD 0.07 /DNA), polyoxazoline‐based developed to mediate tumor vascular normalization extracellular matrix (ECM) degradation cancer The aldehyde groups of OHC‐PEG‐CHO can form Schiff base bonds with the amine PER PEtOx ), thereby enabling in situ encapsulation PERD PER/DNA) rapid pH responsiveness tissues. possesses excellent vitro transfection performance good biocompatibility. efficiently accumulate, penetrate, transfect tumors once intravenous administration. effectively normalizes vasculature degradates ECM, enhances infiltration function cytotoxic T lymphocytes, inducing antitumor immune response vivo. Moreover, PPERVH ((i.e., /(pshVEGF+pHAase)) also inhibit recurrence metastasis by triggering durable anti‐tumor memory effect. Furthermore, significantly effectiveness checkpoint blockade‐mediated immunotherapy. This strategy provides a promising paradigm inhibiting growth, recurrence, metastasis.

Language: Английский

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