Advancing Cancer Therapy with Nanomaterials Targeting Metalloptosis Mechanisms DOI
Girish Sharma, Anita Mittal, Tarun Kumar Batra

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 503 - 530

Published: April 25, 2025

Despite the widespread use of traditional cancer therapies such as surgery, chemotherapy, and radiation, these approaches often suffer from significant drawbacks. Nanomaterials (NMs) are a promising alternative due to their distinct nanoscale properties which enable more precise drug delivery reduced off-target effects. Recently, cuproptosis ferroptosis have emerged novel forms programmed cell death regulated by metal ions, offering pathways for therapy. Cuproptosis, caused copper ion accumulation, leads mitochondrial dysfunction, while ferroptosis, driven iron-mediated lipid peroxidation, disrupts cellular integrity through oxidative stress. Here, we propose explore how NMs can be harnessed induce metalloptosis, advanced treatment strategies. Variations in NM size, morphology, synergistic effects composite complicate identification individual mechanisms. Use therapy, requires focusing on design regulation metalloptosis pathways.

Language: Английский

Radioresistance in Hepatocellular Carcinoma: Biological Bases and Therapeutic Implications DOI Open Access
Jianhui Wu, Xiaofang Zhao,

Bowen Ren

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1839 - 1839

Published: Feb. 21, 2025

Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. Radiotherapy technology common treatment modality that can be used in all stages of HCC. However, some cases, radiotherapy fails clinical practice mainly because the patient’s resistance to radiotherapy, creating bottleneck for future breakthroughs. HCC radiosensitivity primarily related DNA double-strand break repair, cellular autophagy, cell cycle, metabolism, hypoxic environmental regulators. Therefore, comprehensive understanding its molecular mechanisms will immense importance reversing radioresistance. In this review, we provide overview mechanism action on HCC, basis radiation modalities, prospects.

Language: Английский

Citations

0
Advancing Cancer Therapy with Nanomaterials Targeting Metalloptosis Mechanisms DOI
Girish Sharma, Anita Mittal, Tarun Kumar Batra

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 503 - 530

Published: April 25, 2025

Despite the widespread use of traditional cancer therapies such as surgery, chemotherapy, and radiation, these approaches often suffer from significant drawbacks. Nanomaterials (NMs) are a promising alternative due to their distinct nanoscale properties which enable more precise drug delivery reduced off-target effects. Recently, cuproptosis ferroptosis have emerged novel forms programmed cell death regulated by metal ions, offering pathways for therapy. Cuproptosis, caused copper ion accumulation, leads mitochondrial dysfunction, while ferroptosis, driven iron-mediated lipid peroxidation, disrupts cellular integrity through oxidative stress. Here, we propose explore how NMs can be harnessed induce metalloptosis, advanced treatment strategies. Variations in NM size, morphology, synergistic effects composite complicate identification individual mechanisms. Use therapy, requires focusing on design regulation metalloptosis pathways.

Language: Английский

Citations

0