Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges
Zhanli Yang,
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Weiwei Guo,
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Wenhao Yang
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et al.
Materials & Design,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113716 - 113716
Published: Feb. 1, 2025
Language: Английский
Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Language: Английский
The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 390 - 390
Published: March 19, 2025
Three-dimensional
printing
technology
is
transforming
pharmaceutical
manufacturing
by
shifting
from
conventional
mass
production
to
additive
manufacturing,
with
a
strong
emphasis
on
personalized
medicine.
The
integration
of
bioinks
and
AI-driven
optimization
further
enhancing
this
innovation,
enabling
drug
precise
dosages,
tailored
drug-release
profiles,
unique
multi-drug
combinations
that
respond
individual
patient
needs.
This
advancement
significantly
impacting
healthcare
accelerating
development,
encouraging
innovative
designs,
treatment
efficacy.
Traditional
follows
one-size-fits-all
approach,
which
often
fails
meet
the
specific
requirements
patients
medical
conditions.
In
contrast,
3D
printing,
coupled
bioink
formulations,
allows
for
on-demand
production,
reducing
dependency
large-scale
storage.
AI-powered
design
process
refine
dosage
forms,
printability,
release
mechanisms,
ensuring
precision
efficiency
in
manufacturing.
These
advancements
have
potential
lower
overall
costs
while
improving
adherence
medication
regimens.
review
explores
potential,
challenges,
environmental
benefits
positioning
it
as
key
driver
next-generation
Language: Английский
A Comprehensive Review on Bioprinted Graphene-Based Material (GBM)-Enhanced Scaffolds for Nerve Guidance Conduits
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(4), P. 213 - 213
Published: March 31, 2025
Peripheral
nerve
injuries
(PNIs)
pose
significant
challenges
to
recovery,
often
resulting
in
impaired
function
and
quality
of
life.
To
address
these
challenges,
guidance
conduits
(NGCs)
are
being
developed
as
effective
strategies
promote
regeneration
by
providing
a
supportive
framework
that
guides
axonal
growth
facilitates
reconnection
severed
nerves.
Among
the
materials
explored,
graphene-based
(GBMs)
have
emerged
promising
candidates
due
their
unique
properties.
Their
properties—such
high
mechanical
strength,
excellent
electrical
conductivity,
favorable
biocompatibility—make
them
ideal
for
applications
repair.
The
integration
3D
printing
technologies
further
enhances
development
GBM-based
NGCs,
enabling
creation
scaffolds
with
complex
architectures
precise
topographical
cues
closely
mimic
natural
neural
environment.
This
customization
significantly
increases
potential
successful
review
offers
comprehensive
overview
properties
GBMs,
principles
printing,
key
design
3D-printed
NGCs.
Additionally,
it
discusses
future
perspectives
research
directions
could
advance
application
GBMs
therapies.
Language: Английский
Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
Abstract
Peripheral
nerve
injury
is
a
common
that
impacts
the
quality
of
life
affected
individuals.
known
to
regenerate
itself
when
defect
small.
The
mechanism
repair
and
regeneration
complex
related
neuroimmunomodulation
where
there
crosstalk
between
Schwann
cells
macrophages
which
respond
smaller
dimensions
immediately.
However,
large
defects
requires
use
grafts.
3D
bioprinting
one
such
promising
technology
with
bioengineered
conduits
can
be
reproduced
for
injured
peripheral
nerves.
This
review
outlines
nerves
provides
detailed
description
latest
developments
in
fabrication
conduits.
Further,
various
techniques
bioinks
have
been
established
vitro
are
discussed.
In
addition,
this
article
aims
look
at
vivo
applications
bioprinted
respect
different
types
models.
challenges
future
perspectives
involved
fabricating
functional
also
Language: Английский