Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future DOI Creative Commons

Chundi Liu,

Mouyuan Sun,

Lining Lin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101503 - 101503

Published: Feb. 6, 2025

Peripheral nerve injuries are a prevalent global issue that has garnered great concern. Although autografts remain the preferred clinical approach to repair, their efficacy is hampered by factors like donor scarcity. The emergence of guidance conduits as novel tissue engineering tools offers promising alternative strategy. This review aims interpret and commercialization from both laboratory perspectives. To enhance comprehension situations, this article provides comprehensive analysis approved United States Food Drug Administration. It proposes initial six months post-transplantation critical window period for evaluating efficacy. Additionally, study conducts systematic discussion on research progress conduits, focusing biomaterials add-on strategies pivotal regeneration, supported literature analysis. conduit materials prospective optimal thoroughly discussed. strategies, together with distinct obstacles potentials deeply analyzed. Based above evaluations, development path manufacturing strategy envisioned. conclusion promoting summarized follows: 1) optimization fundamental means; 2) phased application additional emphasized direction; 3) additive techniques necessary tools. As result, findings provide academic practitioners valuable insights may facilitate future endeavors conduits.

Language: Английский

Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future DOI Creative Commons

Chundi Liu,

Mouyuan Sun,

Lining Lin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101503 - 101503

Published: Feb. 6, 2025

Peripheral nerve injuries are a prevalent global issue that has garnered great concern. Although autografts remain the preferred clinical approach to repair, their efficacy is hampered by factors like donor scarcity. The emergence of guidance conduits as novel tissue engineering tools offers promising alternative strategy. This review aims interpret and commercialization from both laboratory perspectives. To enhance comprehension situations, this article provides comprehensive analysis approved United States Food Drug Administration. It proposes initial six months post-transplantation critical window period for evaluating efficacy. Additionally, study conducts systematic discussion on research progress conduits, focusing biomaterials add-on strategies pivotal regeneration, supported literature analysis. conduit materials prospective optimal thoroughly discussed. strategies, together with distinct obstacles potentials deeply analyzed. Based above evaluations, development path manufacturing strategy envisioned. conclusion promoting summarized follows: 1) optimization fundamental means; 2) phased application additional emphasized direction; 3) additive techniques necessary tools. As result, findings provide academic practitioners valuable insights may facilitate future endeavors conduits.

Language: Английский

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