Complex regulation of cardiac fibrosis: insights from immune cells and signaling pathways DOI Creative Commons

Wutian Rao,

Dan Li,

Qinghang Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Cardiac fibrosis is a physiological process that involves the formation of scar tissue in heart response to injury or damage. This initially protective measure characterized by enhanced fibroblasts, which are responsible for producing extracellular matrix proteins provide structural support heart. However, when becomes excessive, it can lead adverse outcomes, including increasing stiffness and impaired cardiac function, ultimately result failure with poor prognosis. While fibroblasts primary cells involved fibrosis, immune have also been found play vital role its progression. Recent research has shown exert multifaceted effects besides regulation inflammatory response. Advanced techniques such as single-cell sequencing multiomics provided insights into specific subsets complex process. Targeted immunotherapy against gaining traction potential treatment option, but still unclear how achieve this whether distinct different roles. To better understand essential examine classical signaling pathways closely related formation. We focused on unique properties diverse their intercommunications. Therefore, review will delve plasticity heterogeneity roles propose facilitate development anti-fibrosis therapeutic strategies.

Language: Английский

Complex regulation of cardiac fibrosis: insights from immune cells and signaling pathways DOI Creative Commons

Wutian Rao,

Dan Li,

Qinghang Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Cardiac fibrosis is a physiological process that involves the formation of scar tissue in heart response to injury or damage. This initially protective measure characterized by enhanced fibroblasts, which are responsible for producing extracellular matrix proteins provide structural support heart. However, when becomes excessive, it can lead adverse outcomes, including increasing stiffness and impaired cardiac function, ultimately result failure with poor prognosis. While fibroblasts primary cells involved fibrosis, immune have also been found play vital role its progression. Recent research has shown exert multifaceted effects besides regulation inflammatory response. Advanced techniques such as single-cell sequencing multiomics provided insights into specific subsets complex process. Targeted immunotherapy against gaining traction potential treatment option, but still unclear how achieve this whether distinct different roles. To better understand essential examine classical signaling pathways closely related formation. We focused on unique properties diverse their intercommunications. Therefore, review will delve plasticity heterogeneity roles propose facilitate development anti-fibrosis therapeutic strategies.

Language: Английский

Citations

0