Aggregation-Induced Luminescent 3-Phenylpyrano[4,3-b]quinolizine Derivatives as Photosensitizers with Anti-Cancer Properties

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1422 - 1422

Published: March 23, 2025

Photodynamic therapy (PDT) has garnered significant attention as an effective and safe method for cancer therapy, with ongoing efforts to develop new photosensitizers enhance its efficacy. This study aimed novel aggregation-induced emission enhancement (AIEE) properties. A series of 3-phenyl pyrano[4,3-b]quinolizine compounds (3–10) were synthesized by reacting pyrones (1a–e) 2-pyridylacetate (2a) or 2-pyridylacetonitrile (2b) then evaluated their potential photosensitizers. Spectroscopic analyses revealed that all emitted blue green fluorescence in ethanol, wavelengths ranging from 446 nm 515 nm. Compounds 5 6, lacking a substituent at position pyrano[4,3-b]quinolizine, exhibited AIEE behavior aqueous solution. Furthermore, produced reactive oxygen species upon exposure LED light. Notably, 6 demonstrate high singlet (1O2) generation efficiency water-rich solvents, where they tend aggregate, contributing destroy cells. In vitro studies using human colon cells (Colo205) demonstrated potent anti-tumor activity These findings suggest based on possessing properties, are PDT.

Language: Английский

Simulated Dump Yard Microbes Drive Significant Biodegradation of Polypropylene and Polyvinyl Chloride Microplastics

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138545 - 138545

Published: May 9, 2025

Language: Английский