Extracellular membrane particles en route to the nucleus – exploring the VOR complex DOI Creative Commons
Aurelio Lorico, Mark F. Santos, Jana Karbanová

et al.

Biochemical Society Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Intercellular communication is an essential hallmark of multicellular organisms for their development and adult tissue homeostasis. Over the past two decades, attention has been focused on mechanisms based various membrane structures, as illustrated by burst scientific literature in field extracellular vesicles (EVs). These lipid bilayer-bound nano- or microparticles, vehicle-like devices, act regulators biological physiological processes. When EVs are internalized recipient cells, cytoplasmic cargoes can interfere with cellular activities, affecting pathways that regulate cell proliferation, differentiation, migration. In cancer, transfer oncogenic factors, stimulate neo-angiogenesis immunosuppression, reprogram stromal confer drug resistance traits, thereby remodeling surrounding microenvironment. Although underlying EV biogenesis uptake now better understood, little known about spatiotemporal mechanism(s) actions after internalization. this respect, we have shown a fraction endocytosed reaches nuclear compartment via VOR (VAP-A-ORP3-Rab7) complex-mediated docking late endosomes to outer nucleoplasmic reticulum, positioning facilitating into nucleoplasm pores. Here, highlight heterogeneity, governing release donor respectively, focus novel intracellular pathway leading cargoes. We will discuss how intercept it, which could open up new avenues clinical applications other small particles (e.g., retroviruses) implicated.

Language: Английский

Extracellular membrane particles en route to the nucleus – exploring the VOR complex DOI Creative Commons
Aurelio Lorico, Mark F. Santos, Jana Karbanová

et al.

Biochemical Society Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Intercellular communication is an essential hallmark of multicellular organisms for their development and adult tissue homeostasis. Over the past two decades, attention has been focused on mechanisms based various membrane structures, as illustrated by burst scientific literature in field extracellular vesicles (EVs). These lipid bilayer-bound nano- or microparticles, vehicle-like devices, act regulators biological physiological processes. When EVs are internalized recipient cells, cytoplasmic cargoes can interfere with cellular activities, affecting pathways that regulate cell proliferation, differentiation, migration. In cancer, transfer oncogenic factors, stimulate neo-angiogenesis immunosuppression, reprogram stromal confer drug resistance traits, thereby remodeling surrounding microenvironment. Although underlying EV biogenesis uptake now better understood, little known about spatiotemporal mechanism(s) actions after internalization. this respect, we have shown a fraction endocytosed reaches nuclear compartment via VOR (VAP-A-ORP3-Rab7) complex-mediated docking late endosomes to outer nucleoplasmic reticulum, positioning facilitating into nucleoplasm pores. Here, highlight heterogeneity, governing release donor respectively, focus novel intracellular pathway leading cargoes. We will discuss how intercept it, which could open up new avenues clinical applications other small particles (e.g., retroviruses) implicated.

Language: Английский

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