Harnessing Folate Receptors: A Comprehensive Review on the Applications of Folate-Adorned Nanocarriers for the Management of Melanoma DOI

Prajakta Sahane,

Niharika Puri,

Pooja Khairnar

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The advancement in exclusively tailored therapeutic delivery systems has escalated a great deal of interest targeted to augment efficacy and lessen adverse effects. approach promisingly helps surmount the unmet clinical needs conventional therapies, including chemoresistance, limited penetration, side In case melanoma, various receptors were overexpressed on tumor site, among which folate receptor (FR) targeting is considered be progressive for managing melanoma. FRs are macromolecules glycosyl phosphatidylinositol-attached protein that possess globular assembly with greater affinity toward specific ligands. So, functional ligands can utilized design nanocarriers (NCs) effectively bind FRs. Hence, folate-adorned NCs (FNCs) offer benefits such as site-specific targeting, cargo protection, minimizing toxicity. This review focuses insights implications FRs, mechanisms, challenges, advantages FNCs. Further, applications FNCs, liposomes, polymeric NCs, albumin nanoparticles, inorganic liquid crystalline nanogels, have been elaborated melanoma therapy. Likewise, potential FNCs immunotherapy, photodynamic therapy, chemotherapy, gene photothermal imaging exhaustively discussed. Furthermore, translational hurdles solutions discussed detail. present expected give thoughtful ideas researchers, industry stakeholders, formulation scientists efficacious development

Language: Английский

Advances in Starch-Based Nanocomposites for Functional Food Systems: Harnessing AI and Nuclear Magnetic Resonance Technologies for Tailored Stability and Bioactivity DOI Creative Commons
Yue Sun, Ziyu Wang,

Jian Ye

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 773 - 773

Published: Feb. 24, 2025

Starch-based nanocomposites (SNCs) are at the forefront of innovations in food science, offering unparalleled opportunities for enhancing stability, bioactivity, and overall functionality systems. This review delves into potential SNCs to address contemporary challenges formulation, focusing on synergistic effects their components. By integrating cutting-edge technologies, such as artificial intelligence (AI) nuclear magnetic resonance (NMR), we explore new avenues precision, predictability, SNCs. AI is applied optimize design SNCs, leveraging predictive modeling fine-tune material properties streamline production processes. The role NMR also critically examined, with particular emphasis its capacity provide high-resolution structural insights, monitor stability over time, elucidate molecular interactions within matrices. Through detailed examples, highlights impact unraveling complex behaviors bioactive compounds encapsulated Additionally, discuss integration functional assays AI-driven analytics assessing bioactivity sensory these systems, providing a robust framework rational advanced products. synergy between AI, NMR, opens pathways developing tailored, high-performance formulations that both health consumer preferences.

Language: Английский

Citations

0

Bacteriophage-Based Therapies in Oral Cancer: A New Frontier in Oncology DOI Creative Commons

Vishnu Priya Panneerselvam,

Leela Kagithakara Vajravelu,

Rahul Harikumar Lathakumari

et al.

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0

Harnessing Folate Receptors: A Comprehensive Review on the Applications of Folate-Adorned Nanocarriers for the Management of Melanoma DOI

Prajakta Sahane,

Niharika Puri,

Pooja Khairnar

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The advancement in exclusively tailored therapeutic delivery systems has escalated a great deal of interest targeted to augment efficacy and lessen adverse effects. approach promisingly helps surmount the unmet clinical needs conventional therapies, including chemoresistance, limited penetration, side In case melanoma, various receptors were overexpressed on tumor site, among which folate receptor (FR) targeting is considered be progressive for managing melanoma. FRs are macromolecules glycosyl phosphatidylinositol-attached protein that possess globular assembly with greater affinity toward specific ligands. So, functional ligands can utilized design nanocarriers (NCs) effectively bind FRs. Hence, folate-adorned NCs (FNCs) offer benefits such as site-specific targeting, cargo protection, minimizing toxicity. This review focuses insights implications FRs, mechanisms, challenges, advantages FNCs. Further, applications FNCs, liposomes, polymeric NCs, albumin nanoparticles, inorganic liquid crystalline nanogels, have been elaborated melanoma therapy. Likewise, potential FNCs immunotherapy, photodynamic therapy, chemotherapy, gene photothermal imaging exhaustively discussed. Furthermore, translational hurdles solutions discussed detail. present expected give thoughtful ideas researchers, industry stakeholders, formulation scientists efficacious development

Language: Английский

Citations

0