Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2969 - 2969

Published: March 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Language: Английский

Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment DOI Creative Commons
Yurong Liu,

Yunheng Liu,

Xinting Li

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2461 - 2473

Published: Feb. 1, 2025

Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.

Language: Английский

Citations

1
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2969 - 2969

Published: March 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Language: Английский

Citations

0