Whispers beneath the skin: how microneedles are shaping tomorrow’s therapies
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 28
Published: May 18, 2025
Microneedles
(MNs)
offer
a
minimally
invasive
alternative
to
conventional
patch-based
and
injection-based
drug
delivery
methods.
By
bypassing
first-pass
metabolism
enhancing
skin
permeability,
MNs
significantly
improve
bioavailability.
Their
applications
span
vaccine
administration,
chronic
disease
management,
cosmetic
treatments.
Five
major
types
of
have
been
identified,
each
with
distinct
mechanisms
action.
Recent
research
focuses
on
advanced
manufacturing
techniques,
stimuli-responsive
materials,
combination
therapies.
Common
materials
include
silicon,
hydrogels,
biodegradable
polymers,
growing
interest
in
sustainable
alternatives.
Despite
their
potential,
face
challenges
related
stability,
cost-effective
production,
regulatory
approvals.
Emerging
technologies,
such
as
The
integration
3D
printing,
artificial
intelligence,
biosensing
technologies
is
driving
significant
advancements
personalized
medicine.
Clinical
trials
involving
vaccines,
biologics,
gene
therapies
are
accelerating
path
toward
acceptance.
support
patient
self-administration,
reduce
dependency
healthcare
infrastructure,
expand
global
access
treatment.
telemedicine
remote
monitoring
positions
them
transformative
tool
future
medical
practice.
Language: Английский
Recent advances and perspectives of MicroNeedles for biomedical applications
Biophysical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Microneedles
(MN)
technology
has
emerged
as
a
transformative
tool
within
the
biomedical
field,
offering
innovative
solutions
to
challenges
in
drug
delivery,
diagnostics,
and
therapeutic
applications.
This
review
article
provides
an
in-depth
exploration
of
diverse
perspectives
applications
MNs,
shedding
light
on
their
pivotal
role
shaping
future
research
clinical
practice.
It
begins
by
elucidating
fundamental
principles
MNs:
design,
fabrication
techniques,
materials,
highlighting
capacity
for
minimally
invasive
access
skin
underlying
tissues.
These
attributes
have
driven
advancements
transdermal
facilitating
precise
controlled
administration
therapeutics,
vaccines,
biologics,
thus
improving
patient
compliance
treatment
outcomes.
Furthermore,
this
investigates
growing
range
including
biomarker
extraction,
interstitial
fluid
(ISF)
analysis,
continuous
glucose
monitoring.
MNs
enable
real-time
monitoring
biochemical
markers
potential
revolutionize
disease
personalized
medicine,
wellness
Their
compatibility
with
microfluidic
systems
further
enhances
point-of-care
testing.
serves
comprehensive
guide,
breadth
opportunities
leveraging
improve
healthcare
outcomes
emphasizing
need
continued
development
dynamic
field.
Language: Английский