Extracellular Vesicle-Based Drug Delivery Systems in Cancer Therapy DOI Open Access

Jiahao Wu,

Z.X. Jin,

Tao Fu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4835 - 4835

Published: May 19, 2025

Extracellular vesicles (EVs) are lipid bilayer-enclosed particles secreted by cells and ubiquitously present in various biofluids. They not only mediate intercellular communication but also serve as promising drug carriers that capable of delivering therapeutic agents to target through their inherent physicochemical properties. In this review, we summarized the recent advances EV isolation techniques innovative drug-loading strategies. Furthermore, emphasized distinct advantages applications EVs derived from different cellular sources cancer treatment. Finally, critically evaluated ongoing clinical trials utilizing for delivery systematically assessed both opportunities challenges associated with implementing EV-based systems therapy.

Language: Английский

Mechanisms of tumor-associated macrophages in breast cancer and treatment strategy DOI Creative Commons
Hong Jin,

Xinyue Meng,

Jianwei Feng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Breast cancer (BC) is the most common in women and a leading cause of cancer-related mortality. Despite advances screening treatment, outcomes for advanced or recurrent BC remain poor, highlighting need new strategies. Recent research emphasizes tumor microenvironment (TME), particularly tumor-associated macrophages (TAMs), as key drivers growth, metastasis, resistance to therapy. The presence M2-like TAMs TME promotes immune evasion progression across subtypes. This review summarizes classification, their role BC, emerging therapies targeting TAMs, including depletion, inhibition recruitment, reprogramming from pro-tumoral M2 anti-tumoral M1 phenotypes. Targeting offers promising strategy improve treatment outcomes.

Language: Английский

Citations

0
Edible ginseng-derived exosomes as drug delivery vehicles reduce the dose and improve the anti-cancer effect of CDDP DOI

Shuiyue Yang,

Jia Guo, Shan Huang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151658 - 151658

Published: March 1, 2025

Language: Английский

Citations

0
Extracellular Vesicle-Based Drug Delivery Systems in Cancer Therapy DOI Open Access

Jiahao Wu,

Z.X. Jin,

Tao Fu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4835 - 4835

Published: May 19, 2025

Extracellular vesicles (EVs) are lipid bilayer-enclosed particles secreted by cells and ubiquitously present in various biofluids. They not only mediate intercellular communication but also serve as promising drug carriers that capable of delivering therapeutic agents to target through their inherent physicochemical properties. In this review, we summarized the recent advances EV isolation techniques innovative drug-loading strategies. Furthermore, emphasized distinct advantages applications EVs derived from different cellular sources cancer treatment. Finally, critically evaluated ongoing clinical trials utilizing for delivery systematically assessed both opportunities challenges associated with implementing EV-based systems therapy.

Language: Английский

Citations

0