Development of a Self-Healing, Tissue-Adhesive, and Bacteriostatic Guar Gum-Based Hydrogel for Enhanced Wound Healing and Tissue Regeneration DOI
Sheetal Jaiswal,

Vivek Kumar Sharma,

Deepak Kumar

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

A guar gum (GG)-grafted-(polydimethylamino-co-polyacrylamido sulfonic acid) [GG-g-(PDMAEA-co-PAMPS)] hydrogel was developed as a promising material for wound dressings. The synthesized by grafting poly(dimethylaminoethacrylate) (PDMAEA) and poly(acrylamidopropyl (PAMPS) onto (GG), its structure confirmed Fourier transform infrared (FTIR) X-ray diffraction (XRD) analyses. Rheological assessments demonstrated mechanical robustness self-healing properties while swelling studies revealed pH-sensitive behavior. Biocompatibility through cell viability assays, showing minimal cytotoxicity the exhibited bacteriostatic effect against Escherichia coli, Staphylococcus aureus, Enterococcus faecalis. In rat full-thickness chronic model, significantly accelerated healing, enhanced collagen deposition, reduced inflammation, promoted angiogenesis. These results underscored potential of GG-g-(PDMAEA-co-PAMPS) an effective solution management.

Language: Английский

Hyaluronic acid and ZIF-8 nanocomposites for wound care DOI
Chou‐Yi Hsu, Saade Abdalkareem Jasim, Ebraheem Abdu Musad Saleh

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144475 - 144475

Published: May 1, 2025

Language: Английский

Citations

1
Recent trends in hydrogel-based formulation for the treatment of diabetic wounds: A Review DOI
Bedanta Bhattacharjee,

K Sandhanam,

Damanbhalang Rynjah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106848 - 106848

Published: March 1, 2025

Language: Английский

Citations

0
Development of a Self-Healing, Tissue-Adhesive, and Bacteriostatic Guar Gum-Based Hydrogel for Enhanced Wound Healing and Tissue Regeneration DOI
Sheetal Jaiswal,

Vivek Kumar Sharma,

Deepak Kumar

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

A guar gum (GG)-grafted-(polydimethylamino-co-polyacrylamido sulfonic acid) [GG-g-(PDMAEA-co-PAMPS)] hydrogel was developed as a promising material for wound dressings. The synthesized by grafting poly(dimethylaminoethacrylate) (PDMAEA) and poly(acrylamidopropyl (PAMPS) onto (GG), its structure confirmed Fourier transform infrared (FTIR) X-ray diffraction (XRD) analyses. Rheological assessments demonstrated mechanical robustness self-healing properties while swelling studies revealed pH-sensitive behavior. Biocompatibility through cell viability assays, showing minimal cytotoxicity the exhibited bacteriostatic effect against Escherichia coli, Staphylococcus aureus, Enterococcus faecalis. In rat full-thickness chronic model, significantly accelerated healing, enhanced collagen deposition, reduced inflammation, promoted angiogenesis. These results underscored potential of GG-g-(PDMAEA-co-PAMPS) an effective solution management.

Language: Английский

Citations

0