ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
A guar gum (GG)-grafted-(polydimethylamino-co-polyacrylamido sulfonic acid) [GG-g-(PDMAEA-co-PAMPS)] hydrogel was developed as a promising material for wound dressings. The synthesized by grafting poly(dimethylaminoethacrylate) (PDMAEA) and poly(acrylamidopropyl (PAMPS) onto (GG), its structure confirmed Fourier transform infrared (FTIR) X-ray diffraction (XRD) analyses. Rheological assessments demonstrated mechanical robustness self-healing properties while swelling studies revealed pH-sensitive behavior. Biocompatibility through cell viability assays, showing minimal cytotoxicity the exhibited bacteriostatic effect against Escherichia coli, Staphylococcus aureus, Enterococcus faecalis. In rat full-thickness chronic model, significantly accelerated healing, enhanced collagen deposition, reduced inflammation, promoted angiogenesis. These results underscored potential of GG-g-(PDMAEA-co-PAMPS) an effective solution management.
Language: Английский