Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: 225, P. 112045 - 112045

Published: March 11, 2025

Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated developing effective therapeutics target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit cell cycle. Senescence has profound effects on both physiological pathological processes, influencing systems through secreted factors that affect surrounding distant Among these exosomes, small extracellular vesicles play crucial roles communication, development, defense, can contribute conditions. Recently, there been increasing interest engineering exosomes as precise drug delivery vehicles, capable targeting specific or intracellular components. Studies have emphasized significant role from senescent progression therapy. Notably, chemotherapeutic agents alter tumor microenvironment, induce trigger immune responses exosome-mediated cargo transfer. This review explores intricate relationship between cancer, examining how different eliminate promote resistance. It also investigates molecular mechanisms signaling pathways driving highlighting current challenges proposing future perspectives uncover new therapeutic strategies for treatment.

Language: Английский

Study on creep hardening-damage constitutive model of cemented tailings backfill based on time-harden theory

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0319470 - e0319470

Published: March 31, 2025

The wide application of the fill mining method is necessary for practicing development concept “green mountains are golden mountains” and protecting surface landscape. In underground quarry, cemented tailings backfill (CTB) mainly subjected to gravity overlying rock layer in area, which will cause creep problems long term. order protect long-term stability mine surface, study hardening-damage characteristics CTB under uniaxial action, maintenance age 28d, cement-tailings ratios 1:6 carry out grading loading test, combined with theory time hardening Explore process law construction isomorphic model. results show that differences filler caused by joint existence damage effects. stage decelerated creep, plays a major role; stabilized play accelerated effect dominant; strength strong then weakened, ultimately, cumulative too large produce “Y” type damage. intrinsic model constructed based on time-hardening better characterizes different stress levels. K r material constants CTB, parameter affects during stage, rate isokinetic creep.

Language: Английский