Grifola Frondosa‐Derived Nanoparticles Modulate Tumor‐Associated Neutrophil Plasticity and Enhance Anti‐Tumor Immunity DOI
Yue Yu,

Jintao Huang,

Jialu Xu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Tumor‐associated neutrophils (TANs) play a crucial role in tumor progression, influencing the immune microenvironment and treatment outcomes. However, how to regulate their plasticity remains challenge. In this study, it is found that Grifola frondosa ‐derived nanoparticles (GF NPs) can significantly recruit activate TANs with an anti‐tumor phenotype, which characterized by increased neutrophil infiltration, elevated marker expression, enhanced release of reactive oxygen species (ROS) extracellular traps (NETs). Using BALB/C mouse subcutaneous model New Zealand rabbit situ hepatocellular carcinoma model, GF NPs show impressive ability reduce burden improve survival time. These results highlight as promising immunotherapeutic strategy targeting TANs, offering novel approach cancer modulating TAN phenotype.

Language: Английский

Grifola Frondosa‐Derived Nanoparticles Modulate Tumor‐Associated Neutrophil Plasticity and Enhance Anti‐Tumor Immunity DOI
Yue Yu,

Jintao Huang,

Jialu Xu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Tumor‐associated neutrophils (TANs) play a crucial role in tumor progression, influencing the immune microenvironment and treatment outcomes. However, how to regulate their plasticity remains challenge. In this study, it is found that Grifola frondosa ‐derived nanoparticles (GF NPs) can significantly recruit activate TANs with an anti‐tumor phenotype, which characterized by increased neutrophil infiltration, elevated marker expression, enhanced release of reactive oxygen species (ROS) extracellular traps (NETs). Using BALB/C mouse subcutaneous model New Zealand rabbit situ hepatocellular carcinoma model, GF NPs show impressive ability reduce burden improve survival time. These results highlight as promising immunotherapeutic strategy targeting TANs, offering novel approach cancer modulating TAN phenotype.

Language: Английский

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